Zhu Rui, Shen Ziyuan, Zhu Haijuan, Zhang Jisen, Xing Xing, Wang Shengyou, Fang Jialiu
Department of Anesthesiology, Hefei Maternal and Child Health Hospital, Anhui Maternal and Child Health Care Hospital, Hefei Fifth People's Hospital, Maternal and Child Health Care Hospital of Anhui Medical University, Hefei, China.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
Cancer Control. 2025 Jan-Dec;32:10732748251355841. doi: 10.1177/10732748251355841. Epub 2025 Jun 28.
Soft Tissue and Other Extraosseous Sarcomas (STOES) represent a rare and heterogeneous group of malignancies with significant clinical challenges due to their complexity and aggressiveness. Despite their low prevalence, the global impact of STOES is substantial, necessitating a detailed examination of their epidemiology and disease burden. This comprehensive analysis utilized data from the Global Health Data Exchange (GHDx) covering the years 1990 to 2021. We assessed the incidence, prevalence, mortality, and Disability-Adjusted Life Years (DALYs) for STOES, categorized by location, sex, and socio-demographic indices. Statistical methods included Estimated Annual Percentage Change (EAPC), Spearman correlation analysis, and Bayesian age-period-cohort modeling. In 2021, STOES cases reached a global prevalence of 480,473, a significant increase from 1990. High Socio-Demographic Index (SDI) regions exhibited the highest age-standardized incidence and prevalence rates (ASIR and ASPR) at 2.05 and 10.61 per 100,000 population, respectively. Notably, significant increases were also observed in Central Asia, Central Europe, and Southern Sub-Saharan Africa. Males consistently showed higher disease rates than females. The decomposition analysis highlighted population growth and aging as primary drivers of the observed trends. Forecasting suggests a decline in the global STOES burden by 2030, though disparities will persist, particularly among males. The study reveals critical geographic and demographic disparities in the burden of STOES, underscoring the ongoing higher risk among males and in certain global regions. Despite projected declines in overall disease burden by 2030, substantial disparities are expected to persist, necessitating targeted public health interventions and robust policies to effectively mitigate these differences and enhance global health outcomes.
软组织及其他骨外肉瘤（STOES）是一类罕见且异质性的恶性肿瘤，因其复杂性和侵袭性而带来重大临床挑战。尽管其发病率较低，但STOES对全球的影响却相当大，因此有必要对其流行病学和疾病负担进行详细研究。这项全面分析利用了全球卫生数据交换中心（GHDx）1990年至2021年的数据。我们评估了STOES的发病率、患病率、死亡率和伤残调整生命年（DALYs），并按部位、性别和社会人口学指数进行分类。统计方法包括估计年百分比变化（EAPC）、Spearman相关性分析和贝叶斯年龄-时期-队列模型。2021年，全球STOES病例的患病率达到480,473例，较1990年有显著增加。高社会人口学指数（SDI）地区的年龄标准化发病率和患病率（ASIR和ASPR）最高，分别为每10万人2.05例和10.61例。值得注意的是，中亚、中欧和撒哈拉以南非洲南部地区也出现了显著增长。男性的发病率一直高于女性。分解分析突出了人口增长和老龄化是观察到的趋势的主要驱动因素。预测表明，到2030年全球STOES负担将有所下降，不过差异仍将存在，尤其是在男性中。该研究揭示了STOES负担在地理和人口统计学上的关键差异，强调了男性及某些全球区域持续存在的较高风险。尽管预计到2030年总体疾病负担会下降，但预计显著差异仍将持续，因此需要有针对性的公共卫生干预措施和有力政策，以有效缩小这些差异并改善全球健康状况。
