Rychlik Andrzej, Kaczmar Ewa, Mikulska Ida, Makowska Krystyna
Department of Clinical Diagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-719, Olsztyn, Poland.
Student Scientific Club of Imaging Techniques in Diagnostics of Small Animal Diseases, Department of Clinical Dagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-719, Olsztyn, Poland.
BMC Vet Res. 2025 Jul 2;21(1):417. doi: 10.1186/s12917-025-04862-1.
Endoscopic examinations are increasingly used in veterinary medicine. Examination using flexible endoscopes is limited to the anterior gastrointestinal tract (panendoscopy) and colon (colonoscopy), while a significant part of the small intestine remains unexamined. Capsular endoscopy is increasingly used, allowing macroscopic assessment of the entire digestive tract. The current study assessed the effect of prokinetic drugs on transit time and cleanliness of the tested part of the digestive tract in capsule endoscopy.
The study aimed to evaluate the usefulness of two prokinetic drugs (metoclopramide and cisapride) in capsule endoscopy studies while assessing the quality of the macroscopic image. Each animal included into the study had endoscopic examination three times - without the administration of prokinetic drugs, after receiving metoclopramide and after receiving cisapride.
The total passage time of the capsule through the gastrointestinal tract was the longest in the group receiving metoclopramide (691.33 min) and the shortest in the group receiving cisapride (584.17 min). The best quality images were observed in the control group.
This research has confirmed the hypothesis that administration of prokinetic drugs increases the probability of recording the entire macroscopic image of the gastrointestinal tract during endoscopy in dogs. A negative feature of their administration is significantly reduced recording quality because of the level of cleanliness of the tested gastrointestinal section.
内镜检查在兽医学中的应用越来越广泛。使用柔性内镜的检查仅限于上消化道（全内镜检查）和结肠（结肠镜检查），而小肠的很大一部分仍未得到检查。胶囊内镜的应用越来越多，可对整个消化道进行宏观评估。本研究评估了促动力药物对胶囊内镜检查中消化道受试部位的通过时间和清洁度的影响。
本研究旨在评估两种促动力药物（甲氧氯普胺和西沙必利）在胶囊内镜检查中的有效性，同时评估宏观图像的质量。纳入研究的每只动物均接受三次内镜检查——未给予促动力药物时、给予甲氧氯普胺后以及给予西沙必利后。
胶囊通过胃肠道的总通过时间在接受甲氧氯普胺的组中最长（691.33分钟），在接受西沙必利的组中最短（584.17分钟）。对照组观察到的图像质量最佳。
本研究证实了以下假设，即给予促动力药物会增加犬类内镜检查期间记录整个胃肠道宏观图像的概率。其给药的一个负面特征是，由于受试胃肠道段的清洁程度，记录质量显著降低。
