Swedish University of Agricultural Sciences, Uppsala, Sweden.
The University of Guelph, Guelph, Canada.
J Vet Intern Med. 2024 Sep-Oct;38(5):2454-2463. doi: 10.1111/jvim.17168. Epub 2024 Aug 24.
Video capsule endoscopy is a noninvasive technique for evaluation of the gastrointestinal tract.
To investigate the safety of using the video capsule ALICAM in dogs with chronic enteropathy (CE) >10 kg, and to compare macroscopic gastrointestinal morphology between CE dogs and healthy controls (HC).
Fifteen CE dogs and 15 similarly breed, age and body weight matched HC.
All dogs underwent a clinical work up including blood analyses, fecal samples, abdominal ultrasonographic examination, and blood pressure measurement. The dogs were withheld from food for 16 hours before and 8 hours after they PO received an ALICAM. All recordings were quality assessed, and blindly evaluated by 2 trained observers.
The median age of CE dogs and HC was 3.3 (interquartile range [IQR] 2.5-5.9) years and 4.7 (IQR 3.3-5.6) years, respectively. The median body weight in the CE dogs and HC was 25.9 (IQR 20.6-30.9) kg, and 29 (IQR 16.2-30.5) kg, respectively. Complete recordings of the gastrointestinal tract were obtained from all dogs without complications. No significant differences were found between groups regarding number of abnormalities such as irregular mucosa, erythema, nonbleeding erosions, bleeding erosions, and dilated lacteals, as well as severity and extent of the abnormalities.
The use of ALICAM for evaluation of the gastrointestinal tract in CE dogs and HC seems safe and feasible regarding gastrointestinal transit and macroscopic morphology assessment in dogs >10 kg. Abnormalities were found in similar proportions in CE dogs and HC.
视频胶囊内镜是一种非侵入性技术,用于评估胃肠道。
研究在患有慢性肠炎(CE)>10kg 的犬中使用视频胶囊 ALICAM 的安全性,并比较 CE 犬和健康对照(HC)之间的宏观胃肠道形态。
15 只 CE 犬和 15 只相似品种、年龄和体重匹配的 HC。
所有犬均进行了临床检查,包括血液分析、粪便样本、腹部超声检查和血压测量。在 PO 接受 ALICAM 之前和之后,犬禁食 16 小时和 8 小时。所有记录均进行了质量评估,并由 2 名经过培训的观察者进行了盲法评估。
CE 犬和 HC 的中位年龄分别为 3.3(四分位距 [IQR] 2.5-5.9)岁和 4.7(IQR 3.3-5.6)岁。CE 犬和 HC 的中位体重分别为 25.9(IQR 20.6-30.9)kg 和 29(IQR 16.2-30.5)kg。所有犬均获得了完整的胃肠道记录,无并发症。两组之间在异常数量(如不规则黏膜、红斑、非出血性糜烂、出血性糜烂和扩张的乳糜管)以及异常的严重程度和范围方面均无显著差异。
在 CE 犬和 HC 中,使用 ALICAM 评估胃肠道的安全性和可行性似乎良好,可用于评估>10kg 犬的胃肠道传输和宏观形态。CE 犬和 HC 中均发现存在异常。