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淀粉样蛋白聚集体中的构象可塑性：从结构刚性到功能适应性的范式转变。

Conformational Plasticity in Amyloid Assemblies: A Paradigm Shift from Structural Rigidity to Functional Adaptability.

作者信息

Weible Alan H, Wang Xiaoguang

机构信息

William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210, United States.

Sustainability Institute, The Ohio State University, Columbus, Ohio 43210, United States.

出版信息

ACS Cent Sci. 2025 Jun 6;11(6):828-830. doi: 10.1021/acscentsci.5c00983. eCollection 2025 Jun 25.

DOI:10.1021/acscentsci.5c00983
PMID:40606003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12221075/
Abstract

The divergence of conformational ensembles of hIAPP in response to different types of mutations and PTMs has been decoded by leveraging the scanning tunneling microscopy-based probability interpretation technique.

摘要

通过利用基于扫描隧道显微镜的概率解释技术，已解码出人胰岛淀粉样多肽（hIAPP）构象集合对不同类型突变和翻译后修饰（PTM）的响应差异。

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本文引用的文献

1
Submolecular Resolution of β‑Sheet Plasticity: Decoding Mutations and PTMs in Protein Aggregation Disorders.β-折叠可塑性的亚分子分辨率：解码蛋白质聚集性疾病中的突变和翻译后修饰
ACS Cent Sci. 2025 May 16;11(6):927-937. doi: 10.1021/acscentsci.5c00421. eCollection 2025 Jun 25.
2
β-Sheet Assembly Translates Conservative Single-Site Mutation into a Perturbation in Macroscopic Structure.β-折叠组装将保守的单点突变转化为宏观结构的扰动。
Nano Lett. 2023 Mar 22;23(6):2370-2378. doi: 10.1021/acs.nanolett.3c00311. Epub 2023 Mar 10.
3
Role of mutations and post-translational modifications in systemic AL amyloidosis studied by cryo-EM.
通过低温电子显微镜研究系统性 AL 淀粉样变性中的突变和翻译后修饰的作用。
Nat Commun. 2021 Nov 5;12(1):6434. doi: 10.1038/s41467-021-26553-9.
4
Challenges in sample preparation and structure determination of amyloids by cryo-EM.冷冻电镜技术在淀粉样纤维样品制备和结构解析方面面临的挑战。
J Biol Chem. 2021 Aug;297(2):100938. doi: 10.1016/j.jbc.2021.100938. Epub 2021 Jul 3.
5
Principles that govern the folding of protein chains.指导蛋白质链折叠的原则。
Science. 1973 Jul 20;181(4096):223-30. doi: 10.1126/science.181.4096.223.