淀粉样蛋白聚集体中的构象可塑性：从结构刚性到功能适应性的范式转变。
Conformational Plasticity in Amyloid Assemblies: A Paradigm Shift from Structural Rigidity to Functional Adaptability.
作者信息
Weible Alan H, Wang Xiaoguang
机构信息
William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210, United States.
Sustainability Institute, The Ohio State University, Columbus, Ohio 43210, United States.
出版信息
ACS Cent Sci. 2025 Jun 6;11(6):828-830. doi: 10.1021/acscentsci.5c00983. eCollection 2025 Jun 25.
Abstract
The divergence of conformational ensembles of hIAPP in response to different types of mutations and PTMs has been decoded by leveraging the scanning tunneling microscopy-based probability interpretation technique.
摘要
通过利用基于扫描隧道显微镜的概率解释技术，已解码出人胰岛淀粉样多肽（hIAPP）构象集合对不同类型突变和翻译后修饰（PTM）的响应差异。
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