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本文引用的文献

1
Severe pulmonary hypertension-interstitial lung disease presenting as right ventricular failure: stabilisation with intravenous prostacyclin and maintenance with inhaled prostacyclin.以右心室衰竭为表现的重度肺动脉高压-间质性肺疾病：静脉注射前列环素实现病情稳定，吸入前列环素维持治疗
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2
Intravenous continuous home inotropic therapy in advanced heart failure: Insights from an observational retrospective study.静脉连续家庭正性肌力治疗在晚期心力衰竭中的应用：一项观察性回顾性研究的见解。
Eur J Intern Med. 2023 Oct;116:65-71. doi: 10.1016/j.ejim.2023.06.010. Epub 2023 Jun 29.
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2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension.2022年欧洲心脏病学会/欧洲呼吸学会肺动脉高压诊断和治疗指南。
Eur Heart J. 2022 Oct 11;43(38):3618-3731. doi: 10.1093/eurheartj/ehac237.
4
Inhaled Treprostinil in Pulmonary Hypertension Due to Interstitial Lung Disease.特发性肺纤维化相关肺动脉高压患者应用吸入曲前列尼尔治疗
N Engl J Med. 2021 Jan 28;384(4):325-334. doi: 10.1056/NEJMoa2008470. Epub 2021 Jan 13.
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Pulmonary hypertension due to interstitial lung disease.特发性肺纤维化相关肺动脉高压
Curr Opin Pulm Med. 2019 Sep;25(5):459-467. doi: 10.1097/MCP.0000000000000599.
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Diagnosis of Idiopathic Pulmonary Fibrosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline.特发性肺纤维化诊断。美国胸科学会/欧洲呼吸学会/日本呼吸学会/拉丁美洲胸科学会临床实践指南。
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Risk assessment in pulmonary arterial hypertension.肺动脉高压的风险评估
Eur Respir J. 2018 Mar 29;51(3). doi: 10.1183/13993003.02606-2017. Print 2018 Mar.
8
Pulmonary Hypertension in Patients with Chronic Fibrosing Idiopathic Interstitial Pneumonias.慢性纤维化性特发性间质性肺炎患者的肺动脉高压
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9
Catecholamine support at the initiation of epoprostenol therapy in pulmonary arterial hypertension.肺动脉高压患者开始使用依前列醇治疗时的儿茶酚胺支持治疗
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[Use of cryoextraction in different types of airway obstruction].[冷冻萃取在不同类型气道阻塞中的应用]
Pneumologie. 2010 Jun;64(6):387-9. doi: 10.1055/s-0029-1244046. Epub 2010 Apr 13.

在重度PH-ILD患者吸入性前列环素滴定过程中，门诊静脉注射多巴酚丁胺作为右心室支持治疗

Outpatient Intravenous Dobutamine as Right Ventricular Support During Inhaled Prostacyclin Uptitration in Severe PH-ILD.

作者信息

Kumar A, Ramanan Siddharth V, Carollo Brett, Swanson Kristen, Parikh Raj

机构信息

Department of Internal Medicine University of Connecticut School of Medicine Farmington Connecticut USA.

Division of Pulmonary, Critical Care and Sleep Hartford Hospital Hartford Connecticut USA.

出版信息

Pulm Circ. 2025 Jul 2;15(3):e70111. doi: 10.1002/pul2.70111. eCollection 2025 Jul.

DOI:10.1002/pul2.70111
PMID:40606041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12215808/
Abstract

PH-ILD carries a poor prognosis, particularly with PVR > 5 WU. The INCREASE trial demonstrated the successful use of inhaled treprostinil, but slow uptitration delays the effects. Our study suggests outpatient IV dobutamine as interim support, improving contractility and reducing PVR during uptitration.

摘要

PH-ILD预后较差，尤其是在肺血管阻力（PVR）>5伍德单位（WU）时。INCREASE试验证明吸入用曲前列尼尔的使用是成功的，但滴定速度缓慢会延迟疗效。我们的研究表明，门诊静脉注射多巴酚丁胺作为过渡支持，可在滴定过程中改善收缩力并降低PVR。