Wang Ling-Li, Xiong Yuan-Bo, Feng Xin-Yi, Liu Ya-Yudie, Su Kai-Xiang, Jiang Si-Yu, Wang Si-Yu, Zhou Ling, Li Shao-Ke, Guo Dan-Dan, Li Rui
Department of Radiology, Affiliated Hospital of North Sichuan Medical College and Sichuan Key Laboratory of Medical Imaging, Nanchong 637000, Sichuan Province, China.
School of Medicine, Jiangsu University, Zhenjiang 212013, Jiangsu Province, China.
World J Radiol. 2025 Jun 28;17(6):107281. doi: 10.4329/wjr.v17.i6.107281.
Pericoronary adipose tissue (PCAT) plays an important role in the pathogenesis and progression of cardiovascular diseases due to its bidirectional communication with the coronary artery wall. In recent years, PCAT parameters measured using coronary computed tomography have emerged as potential noninvasive imaging biomarkers for quantifying coronary artery inflammation, with significant clinical value in the early detection, disease progression assessment, treatment efficacy evaluation, and prognosis prediction of cardiovascular diseases. Furthermore, new technologies such as PCAT radiomics analysis have broadened its potential applications in evaluating coronary plaque vulnerability, predicting cardiovascular events, and improving risk stratification. This review discusses recent advances in PCAT research, focusing on its role in coronary artery disease risk identification and inflammation monitoring, and aims to offer imaging-based insights to support its future clinical use in cardiovascular disease management.
冠状动脉周围脂肪组织（PCAT）由于其与冠状动脉壁的双向交流，在心血管疾病的发病机制和进展中起着重要作用。近年来，使用冠状动脉计算机断层扫描测量的PCAT参数已成为用于量化冠状动脉炎症的潜在非侵入性成像生物标志物，在心血管疾病的早期检测、疾病进展评估、治疗疗效评价和预后预测方面具有重要临床价值。此外，PCAT放射组学分析等新技术拓宽了其在评估冠状动脉斑块易损性、预测心血管事件和改善风险分层方面的潜在应用。本综述讨论了PCAT研究的最新进展，重点关注其在冠状动脉疾病风险识别和炎症监测中的作用，旨在提供基于成像的见解，以支持其未来在心血管疾病管理中的临床应用。
