Akhtar Muhammad Umair, Chilmeran Zaid, Sharafeldin Abu-Baker Khalid, Waly Yahya Mostafa, Khan Mustafa Tariq, Fredericks Salim
School of Medicine, Royal College of Surgeons in Ireland-Bahrain, Al-Muharraq, Bahrain.
Front Med (Lausanne). 2025 Jun 18;12:1567229. doi: 10.3389/fmed.2025.1567229. eCollection 2025.
Septic arthritis is a serious infection that can lead to joint destruction, sepsis, and high mortality rates, particularly in elderly patients and those with comorbid conditions. Comorbidities such as diabetes, rheumatoid arthritis, chronic kidney disease, and liver disease can complicate the diagnosis, treatment, and overall prognosis of the disease. These conditions may impair immune function, delay diagnosis, and hinder effective antimicrobial therapy, thereby increasing the risk of severe complications and poor outcomes. This review explores the impact of comorbidities on the prognosis of patients with septic arthritis, emphasizing the need for tailored management strategies to improve outcomes in this vulnerable population. Understanding the interplay between comorbid conditions and septic arthritis is essential for optimizing treatment approaches and enhancing patient care.
脓毒性关节炎是一种严重感染，可导致关节破坏、脓毒症和高死亡率，尤其是在老年患者和患有合并症的患者中。糖尿病、类风湿性关节炎、慢性肾病和肝病等合并症会使该疾病的诊断、治疗及总体预后复杂化。这些病症可能损害免疫功能、延迟诊断并阻碍有效的抗菌治疗，从而增加严重并发症和不良结局的风险。本综述探讨合并症对脓毒性关节炎患者预后的影响，强调需要制定针对性的管理策略以改善这一脆弱人群的结局。了解合并症与脓毒性关节炎之间的相互作用对于优化治疗方法和加强患者护理至关重要。
