David P, Gaillard J A
C R Acad Hebd Seances Acad Sci D. 1977 Mar 28;284(13):1223-6.
Using the technique of 3 dimensional reconstruction, the various steps involved in the formation and growth of the crown of a tooth primordium observed in a complex ovarian teratoma have been compared with that occurring in dermoid cysts and in the normal dental system. Inside dermoid cysts, the characteristic form of the tooth is established during the production of the dentine and enamel and the process is often similar to that occurring during normal tooth development. In teratomas, however, organogenesis and morphogenesis take place within a system undergoing multidirectional development. They are dissociated during both the embryonic stage and that of a structural formation. Morphogenesis is the most disturbed and the role of the environment is presumably therefore very important.
利用三维重建技术，将在复杂卵巢畸胎瘤中观察到的牙原基牙冠形成和生长所涉及的各个步骤，与皮样囊肿和正常牙齿系统中的情况进行了比较。在皮样囊肿内，牙齿的特征形态在牙本质和釉质形成过程中确立，且该过程通常与正常牙齿发育过程相似。然而，在畸胎瘤中，器官发生和形态发生发生在一个经历多向发育的系统内。它们在胚胎期和结构形成期均发生分离。形态发生受到的干扰最大，因此环境的作用可能非常重要。
