David P, Gaillard J A
Ann Anat Pathol (Paris). 1978;23(4-5):287-308.
The teeth buds which are observed in some teratomas ought to provide a useful system for the study of the development of organ structures in these tumours. They exhibit well defined characteristics in space and time. In contrast with normal development tooth bud formation in teratomas display malformations and other observable characteristics which are primarily the consequence of defects in coordination of activities among cells. Cyto-differentiation appears to be normal and the defective organogenesis must represent a breakdown of the principles which underlie the organization of structures. The possible role of the environment in organizing structure is discussed. Teratomas are unique biological systems which display in a dynamic way a panoply of teratological developmental processes of which teeth buds represent a fragmentary, repetitive and conspicuous expression.
在一些畸胎瘤中观察到的牙胚，应该为研究这些肿瘤中器官结构的发育提供一个有用的系统。它们在空间和时间上表现出明确的特征。与正常发育相反，畸胎瘤中的牙胚形成表现出畸形和其他可观察到的特征，这些主要是细胞间活动协调缺陷的结果。细胞分化似乎是正常的，而有缺陷的器官发生必定代表了构成结构组织基础的原则的崩溃。本文讨论了环境在组织结构形成中的可能作用。畸胎瘤是独特的生物系统，它以动态方式展示了一系列的致畸发育过程，其中牙胚代表了一种不完整、重复且明显的表现形式。
