Chen Qiyu, Xu Yuxin, Lin Jiali, Zhou Qiaoling, Zhou Houqing
Department of Clinical Laboratory, Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen, People's Republic of China.
Department of Clinical Research and Epidemiology, Shenzhen Institute for Cardiovascular Disease, Shenzhen, People's Republic of China.
Infect Drug Resist. 2025 Jun 27;18:3187-3197. doi: 10.2147/IDR.S513994. eCollection 2025.
is a rapidly growing non-tuberculous mycobacterium that requires 3 to 5 days of cultivation for colonies to become visible to the naked eye, with most exhibiting vigorous growth during this initial week. It does not readily grow in standard bacterial culture conditions, posing challenges that often result in missed or incorrect diagnoses, and necessitating an extended course of anti-infective treatment.
This case report describes a rare instance of wound infection caused by in a 64-year-old female patient who underwent mitral valve bioprosthesis replacement and temporary cardiac pacemaker implantation. In the postoperative period, the patient exhibited signs of infection, including elevated leukocyte count and neutrophil percentage, along with serous discharge from the surgical wound. was definitively identified using 16sRNA gene sequencing. The patient responded well to a combination therapy consisting of amikacin, azithromycin, and moxifloxacin, complemented by surgical debridement.
, which require extended cultivation periods for visible colony formation, often result in underdetection. The atypical presentation of clinical symptoms can further delay the initiation of appropriate antibiotic therapy. This case underscores the critical role of prolonged cultivation time in detecting and highlights the importance of confirming genuine infections and the precision of clinical medication based on clinical symptoms and treatment outcomes.
[细菌名称]是一种快速生长的非结核分枝杆菌,其菌落肉眼可见需要3至5天的培养时间,大多数在此初始周内呈现旺盛生长。它在标准细菌培养条件下不易生长,带来了诸多挑战,常导致漏诊或误诊,并且需要延长抗感染治疗疗程。
本病例报告描述了一名64岁女性患者的罕见伤口感染病例,该患者接受了二尖瓣生物瓣膜置换和临时心脏起搏器植入术。术后,患者出现感染迹象,包括白细胞计数和中性粒细胞百分比升高,以及手术伤口有浆液性分泌物。通过16sRNA基因测序明确鉴定出[细菌名称]。患者对由阿米卡星、阿奇霉素和莫西沙星组成的联合治疗反应良好,并辅以手术清创。
[细菌名称]需要较长培养时间才能形成可见菌落,常导致检测不足。临床症状的非典型表现会进一步延迟适当抗生素治疗的开始。本病例强调了延长培养时间在检测[细菌名称]中的关键作用,并突出了基于临床症状和治疗结果确认真正感染以及临床用药精准性的重要性。
需注意,原文中部分细菌名称未给出具体内容,翻译时用[细菌名称]代替。