IgG的4个亚类与人类嗜碱性粒细胞上的CD32b/a相互作用的功效。
Efficacy of the 4 Subclasses of IgG for Interacting With CD32b/a on Human Basophils.
作者信息
MacGlashan Donald, Spiller Benjamin W, Smith Scott A
机构信息
Division of Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, Maryland, USA.
Microbiology and Immunology and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
出版信息
Clin Exp Allergy. 2025 Jul 3. doi: 10.1111/cea.70108.
Abstract
- IgG3 and IgG4 most effectively inhibit basophil activation through CD32b engagement. - IgG2 shows minimal CD32b-dependent inhibition at physiologically relevant concentrations.
摘要
- IgG3和IgG4通过与CD32b结合最有效地抑制嗜碱性粒细胞活化。- IgG2在生理相关浓度下显示出最小的依赖CD32b的抑制作用。
相似文献
1
Efficacy of the 4 Subclasses of IgG for Interacting With CD32b/a on Human Basophils.IgG的4个亚类与人类嗜碱性粒细胞上的CD32b/a相互作用的功效。
Clin Exp Allergy. 2025 Jul 3. doi: 10.1111/cea.70108.
2
The relationship between flavonols intake and stroke in the elderly: a cross-sectional study from NHANES (2007-2010 and 2017-2018).老年人黄酮醇摄入量与中风之间的关系：一项来自美国国家健康与营养检查调查（2007 - 2010年和2017 - 2018年）的横断面研究
J Stroke Cerebrovasc Dis. 2025 Aug;34(8):108373. doi: 10.1016/j.jstrokecerebrovasdis.2025.108373. Epub 2025 Jun 7.
3
Regulation of IgE-mediated signalling in human basophils by CD32b and its role in Syk down-regulation: basic mechanisms in allergic disease.CD32b对人嗜碱性粒细胞中IgE介导信号的调节及其在Syk下调中的作用：变应性疾病的基本机制
Clin Exp Allergy. 2014;44(5):713-23. doi: 10.1111/cea.12155.
4
Functional Interactions of Common Allotypes of Rhesus Macaque FcγR2A and FcγR3A with Human and Macaque IgG Subclasses.恒河猴 FcγR2A 和 FcγR3A 常见同种异型与人类和恒河猴 IgG 亚类的功能相互作用。
J Immunol. 2020 Dec 15;205(12):3319-3332. doi: 10.4049/jimmunol.2000501. Epub 2020 Nov 18.
5
The hemolytic activity of abo antibodies: Correlation between quantitative tests, complement-mediated hemolysis assay (CHUHE-P), and IgG subclasses.ABO抗体的溶血活性：定量检测、补体介导的溶血试验（CHUHE-P）与IgG亚类之间的相关性
Transfus Med. 2025 Aug 9. doi: 10.1111/tme.70005.
6
The association between expression of CD200 on B lymphocytes and the count of eosinophils and basophils in atopic dermatitis patients with and without dupilumab therapy - Pilot study.B 淋巴细胞表面 CD200 表达与接受和未接受度普利尤单抗治疗的特应性皮炎患者嗜酸性粒细胞和嗜碱性粒细胞计数的相关性 - 初步研究。
Int Immunopharmacol. 2024 May 10;132:112023. doi: 10.1016/j.intimp.2024.112023. Epub 2024 Apr 10.
7
Serum Immunoglobulin G Levels Are Associated with Risk for Exacerbations: An Analysis of SPIROMICS.血清免疫球蛋白G水平与急性加重风险相关：SPIROMICS分析
Am J Respir Crit Care Med. 2025 Feb;211(2):215-221. doi: 10.1164/rccm.202311-2184OC.
8
Response of peripheral blood basophils in subjects with chronic spontaneous urticaria during treatment with omalizumab.奥马珠单抗治疗慢性自发性荨麻疹患者外周血嗜碱性粒细胞的反应。
J Allergy Clin Immunol. 2021 Jun;147(6):2295-2304.e12. doi: 10.1016/j.jaci.2021.02.039. Epub 2021 Mar 12.
9
A robust label-free workflow for the immunoglobulin G subclass site-specific N-glycopeptides and the glycosylation of IgG 2 correlated with colorectal cancer.一种用于免疫球蛋白G亚类位点特异性N-糖肽及与结直肠癌相关的IgG 2糖基化的强大无标记工作流程。
Talanta. 2026 Jan 1;296:128326. doi: 10.1016/j.talanta.2025.128326. Epub 2025 May 22.
10
Antibody tests for identification of current and past infection with SARS-CoV-2.抗体检测用于鉴定 SARS-CoV-2 的现症感染和既往感染。
Cochrane Database Syst Rev. 2022 Nov 17;11(11):CD013652. doi: 10.1002/14651858.CD013652.pub2.
本文引用的文献
1
Widespread monoclonal IgE antibody convergence to an immunodominant, proanaphylactic Ara h 2 epitope in peanut allergy.花生过敏中广泛存在的单克隆 IgE 抗体向免疫显性、致过敏的 Ara h 2 表位趋同。
J Allergy Clin Immunol. 2024 Jan;153(1):182-192.e7. doi: 10.1016/j.jaci.2023.08.035. Epub 2023 Sep 23.
2
Subclasses of allergen-specific IgG: Serum IgG2 and IgG3 levels are not predicted by IgG1/IgG4 levels.变应原特异性IgG的亚类：血清IgG2和IgG3水平不能由IgG1/IgG4水平预测。
Clin Exp Allergy. 2021 Aug;51(8):1093-1095. doi: 10.1111/cea.13977. Epub 2021 Jul 20.
3
High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes.从单个 IgE B 细胞转录组中克隆的高亲和力过敏原特异性人抗体。
Science. 2018 Dec 14;362(6420):1306-1309. doi: 10.1126/science.aau2599.
4
Parameters determining the efficacy of CD32 to inhibit activation of FcεRI in human basophils.决定CD32抑制人嗜碱性粒细胞中FcεRI激活功效的参数。
J Allergy Clin Immunol. 2016 Apr;137(4):1256-1258.e11. doi: 10.1016/j.jaci.2015.10.043. Epub 2016 Jan 7.
5
Regulation of IgE-mediated signalling in human basophils by CD32b and its role in Syk down-regulation: basic mechanisms in allergic disease.CD32b对人嗜碱性粒细胞中IgE介导信号的调节及其在Syk下调中的作用：变应性疾病的基本机制
Clin Exp Allergy. 2014;44(5):713-23. doi: 10.1111/cea.12155.
6
IgG antibodies produced during subcutaneous allergen immunotherapy mediate inhibition of basophil activation via a mechanism involving both FcgammaRIIA and FcgammaRIIB.皮下变应原免疫治疗过程中产生的 IgG 抗体通过涉及 FcγRIIA 和 FcγRIIB 的机制介导嗜碱性粒细胞激活的抑制。
Immunol Lett. 2010 May 4;130(1-2):57-65. doi: 10.1016/j.imlet.2009.12.001. Epub 2009 Dec 30.
7
Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen.快速生成针对疫苗接种抗原的完全人源单克隆抗体。
Nat Protoc. 2009;4(3):372-84. doi: 10.1038/nprot.2009.3.
Zotero 插件