• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抗体干扰流感病毒血凝素分子的构象变化作为一种可能的中和机制。

Interference with a conformational change in the haemagglutinin molecule of influenza virus by antibodies as a possible neutralization mechanism.

作者信息

Kida H, Yoden S, Kuwabara M, Yanagawa R

出版信息

Vaccine. 1985 Sep;3(3 Suppl):219-22. doi: 10.1016/0264-410x(85)90110-0.

DOI:10.1016/0264-410x(85)90110-0
PMID:4060852
Abstract

A possible mechanism of neutralization of influenza virus by antibodies to the haemagglutinin molecule is proposed in addition to the generally accepted mechanism of blocking attachment to host cell receptors. This proposed mechanism involves interference with a low-pH-induced conformational change in the haemagglutinin molecule by bivalent binding of antibodies, which results in inhibition of the fusion step in the viral replication process.

摘要

除了普遍认可的阻断与宿主细胞受体结合的机制外，还提出了一种血凝素分子抗体中和流感病毒的可能机制。该机制涉及抗体的二价结合干扰血凝素分子中低pH诱导的构象变化，从而抑制病毒复制过程中的融合步骤。

相似文献

1
Interference with a conformational change in the haemagglutinin molecule of influenza virus by antibodies as a possible neutralization mechanism.抗体干扰流感病毒血凝素分子的构象变化作为一种可能的中和机制。
Vaccine. 1985 Sep;3(3 Suppl):219-22. doi: 10.1016/0264-410x(85)90110-0.
2
Is bivalent binding of monoclonal antibodies to different antigenic areas on the hemagglutinin of influenza virus required for neutralization of viral infectivity?单克隆抗体与流感病毒血凝素上不同抗原区域的二价结合对于中和病毒感染性是否必要？
Arch Virol. 1985;85(3-4):209-16. doi: 10.1007/BF01314232.
3
Spin-labeling of influenza virus hemagglutinin permits analysis of the conformational change at low pH and its inhibition by antibody.流感病毒血凝素的自旋标记可用于分析低pH下的构象变化及其被抗体抑制的情况。
Virus Res. 1986 May;4(3):251-61. doi: 10.1016/0168-1702(86)90004-3.
4
The intersubunit region of the influenza virus haemagglutinin is recognized by antibodies during infection.在感染过程中，流感病毒血凝素的亚基间区域可被抗体识别。
Scand J Immunol. 1994 Sep;40(3):281-91. doi: 10.1111/j.1365-3083.1994.tb03464.x.
5
Antigenic analysis of recent H1N1 influenza viruses with monoclonal antibodies.利用单克隆抗体对近期甲型H1N1流感病毒进行抗原分析。
Acta Virol. 1991 Aug;35(4):343-9.
6
Conformational changes in influenza virus haemagglutinin and its monomer detected by monoclonal antibodies.通过单克隆抗体检测流感病毒血凝素及其单体的构象变化。
Vaccine. 1985 Sep;3(3 Suppl):175-81. doi: 10.1016/0264-410x(85)90099-4.
7
Dissociation of the haemagglutination inhibition and the infectivity neutralization in the reactions of influenza A/USSR/90/77 (H1N1) virus variants with monoclonal antibodies.甲型流感病毒/苏联/90/77（H1N1）病毒变种与单克隆抗体反应中血凝抑制和感染性中和的解离
J Gen Virol. 1986 Oct;67 ( Pt 10):2247-51. doi: 10.1099/0022-1317-67-10-2247.
8
An antibody which binds to the membrane-proximal end of influenza virus haemagglutinin (H3 subtype) inhibits the low-pH-induced conformational change and cell-cell fusion but does not neutralize virus.
J Gen Virol. 1998 Jul;79 ( Pt 7):1781-91. doi: 10.1099/0022-1317-79-7-1781.
9
High and low efficiency neutralization epitopes on the haemagglutinin of type A influenza virus.甲型流感病毒血凝素上的高效和低效中和表位
J Gen Virol. 1997 Oct;78 ( Pt 10):2441-6. doi: 10.1099/0022-1317-78-10-2441.
10
Analyses of the antigenicity of influenza haemagglutinin at the pH optimum for virus-mediated membrane fusion.在病毒介导的膜融合的最适pH值下对流感血凝素抗原性的分析。
J Gen Virol. 1983 Aug;64 (Pt 8):1657-62. doi: 10.1099/0022-1317-64-8-1657.

引用本文的文献

1
Immunological assessment of influenza vaccines and immune correlates of protection.流感疫苗的免疫学评估和保护的免疫相关因素。
Expert Rev Vaccines. 2013 May;12(5):519-36. doi: 10.1586/erv.13.35.
2
Evaluation of diagnostic applications of monoclonal antibodies against avian influenza H7 viruses.抗禽流感H7病毒单克隆抗体的诊断应用评估。
Clin Vaccine Immunol. 2010 Sep;17(9):1398-406. doi: 10.1128/CVI.00023-10. Epub 2010 Jul 21.
3
Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses.
甲型禽流感病毒和人流感病毒广谱中和的结构与功能基础
Nat Struct Mol Biol. 2009 Mar;16(3):265-73. doi: 10.1038/nsmb.1566. Epub 2009 Feb 22.
4
CD4 binding site antibodies inhibit human immunodeficiency virus gp120 envelope glycoprotein interaction with CCR5.CD4结合位点抗体可抑制人类免疫缺陷病毒gp120包膜糖蛋白与CCR5的相互作用。
J Virol. 2003 Jan;77(1):713-8. doi: 10.1128/jvi.77.1.713-718.2003.
5
Mechanisms of human immunodeficiency virus Type 1 (HIV-1) neutralization: irreversible inactivation of infectivity by anti-HIV-1 antibody.1型人类免疫缺陷病毒（HIV-1）的中和机制：抗HIV-1抗体对感染性的不可逆失活作用
J Virol. 1996 Aug;70(8):5236-45. doi: 10.1128/JVI.70.8.5236-5245.1996.
6
A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains.甲型流感病毒H1和H2毒株血凝素之间保守的一个共同中和表位。
J Virol. 1993 May;67(5):2552-8. doi: 10.1128/JVI.67.5.2552-2558.1993.
7
Insights into neutralization of animal viruses gained from study of influenza virus.从流感病毒研究中获得的关于动物病毒中和作用的见解。
Epidemiol Infect. 1991 Apr;106(2):205-20. doi: 10.1017/s0950268800048354.