Bourassa M G
Acta Pharmacol Toxicol (Copenh). 1985;57 Suppl 2:21-30. doi: 10.1111/j.1600-0773.1985.tb03571.x.
This review describes the haemodynamic and electrophysiologic properties of diltiazem and shows how these effects may, in some clinical situations, favour the choice of this drug as an antianginal and antiarrhythmic agent. Compared to nifedipine and verapamil, diltiazem has the distinct advantage of being a negative chronotropic agent and thus has the potential of leading to a greater reduction in myocardial oxygen consumption; it does not affect cardiac output, left ventricular end diastolic pressure, and ejection fraction in patients with an adequately preserved left ventricular function; finally, it possesses a longer duration of action and fewer side effects, even at relatively high calcium entry blocking doses, than the other major calcium entry blockers.
本综述描述了地尔硫䓬的血流动力学和电生理特性，并展示了在某些临床情况下，这些效应如何有利于将该药物选作抗心绞痛和抗心律失常药物。与硝苯地平和维拉帕米相比，地尔硫䓬具有明显的负性变时作用优势，因此有可能更大程度地降低心肌耗氧量；在左心室功能充分保留的患者中，它不影响心输出量、左心室舒张末期压力和射血分数；最后，与其他主要的钙通道阻滞剂相比，即使在相对高的钙通道阻滞剂量下，它也具有更长的作用持续时间和更少的副作用。
