Zhang Zhixia, Song Jiating, Li Ling, Yuan Li
Nursing Department, Guangdong Provincial Hospital of Chinese Medicine Zhuhai, 53 Jingle Road, Zhuhai, Guangdong province, 519015, China.
Ophthalmology and Otolaryngology Department, Guangdong Provincial Hospital of Chinese Medicine Zhuhai, 53 Jingle Road, Zhuhai, Guangdong Province, 519015, China.
BMC Complement Med Ther. 2025 Jul 3;25(1):227. doi: 10.1186/s12906-025-04930-x.
Oral mucositis (OM), as a common adverse effect in patients with chemotherapies, affects the convalescent quality of life. Currently, an increasing number of mouthwashes have been used to improve the incidence of OM in patients undergoing with radiotherapy and chemotherapy. Most studies are comparisons of two arms or three groups, resulting in the lack of direct comparative trial evidence for all care fluids.Therefore, it is not clear which mouthwash is better for preventing the occurrence of OM in patients. This study compares the preventive effects of13 mouthwashes currently used to treat OM in different countries.
A computerized search was performed for randomized controlled trials on the use of mouthwash to prevent OM published in databases, such as PubMed, Embase, Web of Science, The Cochrane Library, and China National Knowledge Infrastructure until April 2023. Two investigators used the Cochrane manual to perform a bias risk assessment of the included RCTs and RevMan5.3 to plot the risk bias. Then, a network meta-analysis of the obtained data was performed using Stata 16.2 software.
A total of 36 randomized controlled trials were included. In the network meta-analysis, the effect of 13 mouthwashes to prevent the occurrence of OM were ranked according to the size of the surface under the cumulative ranking (SUCRA) probability curve value, from best to worst were: aloe vera juice, Chinese herbal medicine, Bing Peng San, honey, Lactobacterium shorti, chamomile, riboflavin, rehabilitation solution, benzydamine, turmeric, aluminum sulfide, povidone-iodine, and chlorhexidine.
According to the SUCRA ranking results, aloe juice can better prevent OM in other chemoradiotherapy patients than other oral mouthwashes. However, this conclusion still needs to be further verified by randomized controlled trials with a larger sample.
Not applicable.
口腔黏膜炎（OM）是化疗患者常见的不良反应，影响患者康复期生活质量。目前，越来越多的漱口水被用于改善放化疗患者的OM发生率。大多数研究为双臂或三组比较，导致缺乏所有护理液的直接对比试验证据。因此，尚不清楚哪种漱口水对预防患者发生OM效果更佳。本研究比较了目前在不同国家用于治疗OM的13种漱口水的预防效果。
对截至2023年4月在PubMed、Embase、Web of Science、Cochrane图书馆和中国知网等数据库中发表的关于使用漱口水预防OM的随机对照试验进行计算机检索。两名研究者使用Cochrane手册对纳入的随机对照试验进行偏倚风险评估，并使用RevMan5.3绘制风险偏倚图。然后，使用Stata 16.2软件对获得的数据进行网络荟萃分析。
共纳入36项随机对照试验。在网络荟萃分析中，根据累积排序曲线下面积（SUCRA）概率曲线值大小对13种漱口水预防OM的效果进行排序，从最佳到最差依次为：芦荟汁、中药、冰硼散、蜂蜜、短双歧杆菌、洋甘菊、核黄素、康复新液、苯佐那酯、姜黄、硫化铝、聚维酮碘和氯己定。
根据SUCRA排序结果，芦荟汁比其他口腔漱口水能更好地预防其他放化疗患者的OM。然而，这一结论仍需通过更大样本量的随机对照试验进一步验证。
不适用。
