Lalla Rajesh V, Brennan Michael T, Gordon Sharon M, Sonis Stephen T, Rosenthal David I, Keefe Dorothy M
Section of Oral Medicine, University of Connecticut Health, Farmington, CT.
Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC.
J Natl Cancer Inst Monogr. 2019 Aug 1;2019(53). doi: 10.1093/jncimonographs/lgz011.
Oral mucositis is a common side-effect associated with conventional cancer therapy and has also recently been reported in association with newly emerging cancer therapies. It is characterized as an inflammation of the oral mucous membranes accompanied by many complex mucosal and submucosal changes. Ulcerative oral mucositis can cause significant oral pain, impair nutritional intake, lead to local or systemic infection, and cause significant economic cost. In addition, it may necessitate interruptions in cancer therapy, thus adversely affecting patient prognosis. This review presents the current understanding of the pathogenesis of mucositis and discusses evidence-based clinical management strategies for oral mucositis. In addition, key research questions for future investigation are identified, followed by a discussion of strategies to promote development and funding of the needed research.
口腔黏膜炎是传统癌症治疗常见的副作用，最近也有报道称其与新出现的癌症治疗方法有关。其特征为口腔黏膜炎症，并伴有许多复杂的黏膜和黏膜下变化。溃疡性口腔黏膜炎可导致严重的口腔疼痛、影响营养摄入、引发局部或全身感染，并造成巨大的经济成本。此外，它可能需要中断癌症治疗，从而对患者预后产生不利影响。本综述阐述了目前对黏膜炎发病机制的认识，并讨论了口腔黏膜炎的循证临床管理策略。此外，还确定了未来研究的关键问题，随后讨论了促进所需研究的开展和资金投入的策略。
