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表没食子儿没食子酸酯通过减少线粒体活性氧生成改善皮肤衰老

Epigallocatechin Gallate in Ameliorates Skin Aging by Reducing Mitochondrial ROS Production.

作者信息

Park Ji Ho, Jeong Eun Young, Kim Ye Hyang, Cha So Yoon, Kim Ha Yeon, Nam Yeon Kyung, Park Jin Seong, Kim So Yeon, Lee Yoo Jin, Yoon Jee Hee, So Byeonghyeon, Kim Duyeol, Kim Minseon, Byun Youngjoo, Lee Yun Haeng, Shin Song Seok, Park Joon Tae

机构信息

Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of Korea.

Hyundai Bioland Co., Ltd., 22, Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si 28162, Republic of Korea.

出版信息

Pharmaceuticals (Basel). 2025 Apr 23;18(5):612. doi: 10.3390/ph18050612.

DOI:10.3390/ph18050612
PMID:40430436
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12114381/
Abstract

Reactive oxygen species (ROS) generated by mitochondrial dysfunction damage cellular organelles and contribute to skin aging. Therefore, strategies to reduce mitochondrial ROS production are considered important for alleviating skin aging, but no effective methods have been identified. In this study, we evaluated substances utilized as cosmetic ingredients and discovered () as a substance that reduces mitochondrial ROS levels. extracts were found to act as senolytics that selectively kill senescent fibroblasts containing dysfunctional mitochondria. In addition, extracts facilitated efficient electron transport in the mitochondrial electron transport chain (ETC) by increasing the efficiency of oxidative phosphorylation (OXPHOS), thereby reducing mitochondrial ROS production, a byproduct of the inefficient ETC. This novel mechanism of extracts led to the restoration of skin aging and the skin barrier. Furthermore, epigallocatechin gallate (EGCG) was identified as an active ingredient that plays a key role in extract-mediated skin aging recovery. Indeed, similar to extracts, EGCG reduced ROS and improved skin aging in an artificial skin model. Our data uncovered a novel mechanism by which extract reverses skin aging by reducing mitochondrial ROS production via selective senescent cell death/increased OXPHOS efficiency. Our results suggest that extract or EGCG may be used as a therapeutic agent to reverse skin aging in clinical and cosmetic applications.

摘要

线粒体功能障碍产生的活性氧（ROS）会损害细胞器并导致皮肤衰老。因此，减少线粒体ROS产生的策略被认为对缓解皮肤衰老很重要，但尚未发现有效的方法。在本研究中，我们评估了用作化妆品成分的物质，并发现（）是一种可降低线粒体ROS水平的物质。提取物被发现可作为衰老细胞溶解剂，选择性杀死含有功能失调线粒体的衰老成纤维细胞。此外，提取物通过提高氧化磷酸化（OXPHOS）效率，促进线粒体电子传递链（ETC）中的高效电子传递，从而减少低效ETC的副产物线粒体ROS的产生。提取物的这种新机制导致皮肤衰老和皮肤屏障的恢复。此外，表没食子儿茶素没食子酸酯（EGCG）被确定为在提取物介导的皮肤衰老恢复中起关键作用的活性成分。事实上，与提取物类似，EGCG在人工皮肤模型中可减少ROS并改善皮肤衰老。我们的数据揭示了一种新机制，即提取物通过选择性衰老细胞死亡/提高OXPHOS效率来减少线粒体ROS产生，从而逆转皮肤衰老。我们的结果表明，提取物或EGCG可作为一种治疗剂，在临床和化妆品应用中逆转皮肤衰老。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/cae2162b87da/pharmaceuticals-18-00612-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/2ecfe9084082/pharmaceuticals-18-00612-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/4398b379902b/pharmaceuticals-18-00612-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/effdb3129969/pharmaceuticals-18-00612-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/7132583c49f9/pharmaceuticals-18-00612-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/36227d1c4346/pharmaceuticals-18-00612-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/6f231c08d032/pharmaceuticals-18-00612-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/2d92b5095e70/pharmaceuticals-18-00612-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/298d79a91b42/pharmaceuticals-18-00612-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/48543d8ba682/pharmaceuticals-18-00612-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/cae2162b87da/pharmaceuticals-18-00612-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/2ecfe9084082/pharmaceuticals-18-00612-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/4398b379902b/pharmaceuticals-18-00612-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/effdb3129969/pharmaceuticals-18-00612-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/7132583c49f9/pharmaceuticals-18-00612-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/36227d1c4346/pharmaceuticals-18-00612-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/6f231c08d032/pharmaceuticals-18-00612-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/2d92b5095e70/pharmaceuticals-18-00612-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/298d79a91b42/pharmaceuticals-18-00612-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/48543d8ba682/pharmaceuticals-18-00612-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5793/12114381/cae2162b87da/pharmaceuticals-18-00612-g010.jpg

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