Pedersen K E, Lysgaard Madsen J, Klitgaard N A, Kjaer K, Hvidt S
Acta Med Scand. 1985;218(2):229-32. doi: 10.1111/j.0954-6820.1985.tb08852.x.
In order to explore the digoxin-quinine interaction, digoxin steady state pharmacokinetics was studied before and during quinine coadministration in seven healthy subjects. Quinine (250 mg/day) increased mean plasma digoxin concentration from 0.64 +/- 0.12 to 0.80 +/- 0.18 ng/ml (p less than 0.05) within one week. Urinary digoxin recovery rose from 154.0 +/- 18.8 to 181.5 +/- 22.6 micrograms/24 h (p less than 0.01), whereas renal digoxin clearance was unaltered in the presence of quinine (181.5 +/- 24.2 vs. 174.1 +/- 26.5 ml/min). An increase in quinine dose (to 750 mg/day) caused further increments in plasma digoxin levels, whereas renal digoxin clearance remained unchanged. Quinine elevates plasma digoxin concentrations in a stepwise fashion probably due to an impairment of extrarenal digoxin clearance.
为了探究地高辛-奎宁相互作用，在7名健康受试者中研究了奎宁联合给药前和给药期间地高辛的稳态药代动力学。奎宁（250毫克/天）在一周内使平均血浆地高辛浓度从0.64±0.12纳克/毫升增至0.80±0.18纳克/毫升（p<0.05）。地高辛尿回收率从154.0±18.8微克/24小时升至181.5±22.6微克/24小时（p<0.01），而在奎宁存在的情况下，肾脏对地高辛的清除率未改变（181.5±24.2对174.1±26.5毫升/分钟）。增加奎宁剂量（至750毫克/天）导致血浆地高辛水平进一步升高，而肾脏对地高辛的清除率保持不变。奎宁可能通过损害肾外地高辛清除率而逐步提高血浆地高辛浓度。
