Laborante Renzo, Ciliberti Giuseppe, Rizzo Gaetano, Canonico Francesco, Paglianiti Donato Antonio, Casamassima Fabio, Restivo Attilio, Cicchella Domenico, Burzotta Francesco, Trani Carlo, Aurigemma Cristina, Galli Mattia, Vergallo Rocco, Porto Italo, Anastasia Gianluca, Sangiorgi Giuseppe Massimo, Massaro Gianluca, Cocco Marta, Biscaglia Simone, Campo Gianluca, Andreini Daniele, Leone Antonio Maria, Crea Filippo, Patti Giuseppe, D'Amario Domenico
Department of Cardiovascular and Thoracic Sciences Catholic University of the Sacred Heart Rome Italy.
Department of Translational Medicine Università del Piemonte Orientale, Division of Cardiology, AOU Maggiore della Carità Novara Italy.
J Am Heart Assoc. 2025 Jul 15;14(14):e040513. doi: 10.1161/JAHA.124.040513. Epub 2025 Jul 3.
Myocardial bridge (MB) is a frequent coronary artery anomaly. The aims of this study are to describe the use of antiplatelet therapy (APT) in a cohort of patients with MB and assess its impact on ischemic and bleeding events.
The RIALTO (Myocardial Bridge Evaluation Towards Personalized Medicine) registry (ID: NCT05111418) is an ambispective multicenter observational registry, enrolling patients with a clinical indication to coronary angiography and evidence of MB. The present analysis included patients with MB without any preexisting indication for APT/anticoagulant therapy according to guidelines. Patients were categorized into 2 groups: single APT or no APT based on discharge prescriptions. The primary end point was the time to first occurrence of net adverse clinical events, defined as a composite of cardiovascular death, nonfatal myocardial infarction, unplanned or elective coronary angiography, ischemic cerebrovascular events, and any bleeding.
Out of 486 enrolled patients with MB, 221 (mean age: 60 years, 66% male) were included in this analysis. One hundred and forty-one patients (64%) received single APT. At a median follow-up of 1661 days, patients with MB receiving single APT had a higher rate of net adverse clinical events (adjusted hazard ratio [aHR], 6.2; =0.03), mainly driven by a higher rate of minor bleeding events (aHR, 10.58; =0.02), with no difference regarding ischemic events. Results were consistent after 1:1 propensity-score matching sensitivity analyses.
The prescription of single APT is common in patients with MB, and it seems to be associated with an increased risk of bleeding, in the absence of a beneficial effect on ischemic events.
