Weaver J E, Maibach H I
Contact Dermatitis. 1977 Apr;3(2):65-8. doi: 10.1111/j.1600-0536.1977.tb03600.x.
Glutaraldehyde (GTA) is an effective preservative in some consumer products. Because it is a weak cutaneous allergen at certain concentrations, studies were conducted to assess any potential hazard of adding a low level (550 ppm) of GTA to an experimental liquid fabric softener. Allergic contact dermatitis (delayed hypersensitivity) was not elicited in challenge tests of 16 GTA-sensitive subjects or in repeated insult patch tests of 706 normal human male and female subjects. The subjects were exposed (1) to the experiment formulation, (2) to the formulation with 10 times the normal level of GTA, and (3) to fabrics laundered with the normal use level or with 10 times the normal use level of these experimental formulations.
戊二醛（GTA）在一些消费品中是一种有效的防腐剂。由于它在某些浓度下是一种轻度皮肤过敏原，因此开展了研究，以评估在一种实验性液体织物柔软剂中添加低水平（550 ppm）GTA的任何潜在危害。在16名对GTA敏感的受试者的激发试验以及706名正常男女受试者的重复刺激斑贴试验中，均未引发过敏性接触性皮炎（迟发型超敏反应）。受试者分别接触（1）实验配方产品、（2）GTA含量为正常水平10倍的配方产品，以及（3）用这些实验配方产品的正常使用水平或正常使用水平10倍洗涤过的织物。
