Alrosan Amjad Z, Alwidyan Tahani, Heilat Ghaith B, Rataan Aseel O, Alrosan Khaled
Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa 13133, Jordan.
Department of General Surgery and Urology, Faculty of Medicine, The Jordan University of Science and Technology, Irbid 22110, Jordan.
Toxicol Rep. 2025 Jun 19;15:102077. doi: 10.1016/j.toxrep.2025.102077. eCollection 2025 Dec.
Breast cancer (BC) poses a global health challenge, necessitating accessible prognostic biomarkers. Systemic inflammatory markers from complete blood counts, such as neutrophil-to-lymphocyte ratio (NLR) and red cell index (RCI), have shown prognostic potential. This retrospective study evaluated the prognostic significance of pre-treatment NLR and RCI for overall survival (OS) in 144 Jordanian BC patients (KAUH, 2011-2025) undergoing chemotherapy. Kaplan-Meier analysis revealed that high pre-treatment NLR (≥ 4.25) and high RCI (≥ 0.02) were significantly associated with shorter OS. Multivariate Cox regression identified elevated pre-treatment RCI (≥ 0.02) and metastasis at diagnosis as independent predictors of increased mortality and worse OS. A significant association between high NLR and RCI values was also observed, suggesting a link between systemic inflammation and erythrocytic dysregulation. In conclusion, pre-treatment RCI and metastasis are strong independent predictors of OS in this cohort, with RCI demonstrating substantial prognostic value.
乳腺癌（BC）是一项全球性的健康挑战，因此需要可获取的预后生物标志物。全血细胞计数得出的全身炎症标志物，如中性粒细胞与淋巴细胞比率（NLR）和红细胞指数（RCI），已显示出预后潜力。这项回顾性研究评估了144例接受化疗的约旦乳腺癌患者（KAUH，2011 - 2025年）治疗前NLR和RCI对总生存期（OS）的预后意义。Kaplan - Meier分析显示，治疗前高NLR（≥4.25）和高RCI（≥0.02）与较短的总生存期显著相关。多变量Cox回归确定治疗前RCI升高（≥0.02）和诊断时转移是死亡率增加和总生存期较差的独立预测因素。还观察到高NLR和RCI值之间存在显著关联，表明全身炎症与红细胞失调之间存在联系。总之，治疗前RCI和转移是该队列总生存期的强有力独立预测因素，RCI显示出显著的预后价值。
