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[撤回] 白藜芦醇激活SIRT1可减轻实验性大鼠蛛网膜下腔出血模型中的脑水肿和神经元凋亡。

[Retracted] SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model.

作者信息

Qian Cong, Jin Jianxiang, Chen Jingyin, Li Jianru, Yu Xiaobo, Mo Hangbo, Chen Gao

机构信息

Department of Neurological Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China.

出版信息

Mol Med Rep. 2025 Sep;32(3). doi: 10.3892/mmr.2025.13603. Epub 2025 Jul 4.

Abstract

Following the publication of the above article, a concerned reader drew to the Editor's attention that, regarding the western blots shown in Fig. 4A on p. 9632, there was a possible break in the continuity of the gel slice representing the β‑actin bands in this figure, such that the protein bands were not shown consecutively as they would have appeared in the affected gel slice. After having conducted an internal investigation, it became apparent that other western blots were potentially affected by the same issue (for example, the data shown in Fig. 4C). The Editor of therefore shares the reader's concern that, beyond reasonable doubt, there were anomalies associated with the presentation of the western blot data in Fig. 4, and on the grounds of a lack of confidence in the presented data, the Editor has decided that the article should be retracted from the publication. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused, and we also thank the reader for bringing this matter to our attention. [Molecular Medicine Reports 16: 9627‑9635, 2017; DOI: 10.3892/mmr.2017.7773].

摘要

上述文章发表后,一位关注此事的读者提请编辑注意,关于第9632页图4A所示的蛋白质免疫印迹法,该图中代表β-肌动蛋白条带的凝胶条带连续性可能存在中断,以至于蛋白质条带并非如在受影响的凝胶条带中那样连续显示。在进行内部调查后,很明显其他蛋白质免疫印迹法可能也受到了同样问题的影响(例如,图4C所示的数据)。因此,《分子医学报告》的编辑认同该读者的担忧,毫无疑问,图4中蛋白质免疫印迹数据的呈现存在异常,基于对所呈现数据缺乏信心,编辑决定将该文章从出版物中撤回。已要求作者对这些问题作出解释,但编辑部未收到答复。编辑就由此造成的不便向读者表示歉意,我们也感谢读者提醒我们注意此事。[《分子医学报告》16: 9627 - 9635, 2017; DOI: 10.3892/mmr.2017.7773]

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