Liu Sihan, Alipour Hiva, Ulanowska Malwina, Zachar Vladimir, Dardmeh Fereshteh
Regenerative Medicine, Department of Health Science and Technology, Aalborg University, Gistrup, Denmark.
Mol Nutr Food Res. 2025 Sep;69(17):e70157. doi: 10.1002/mnfr.70157. Epub 2025 Jul 4.
This study investigated the potential therapeutic effects of Lactobacillus rhamnosus PB01 supplementation on metabolic and reproductive dysfunctions in Type 1 diabetes mellitus (T1DM) rat model. Diabetic rats treated with L. rhamnosus PB01 (1 × 10⁹ CFU/day) showed significant improvements in metabolic and reproductive outcomes. Specifically, diabetes-induced weight loss was mitigated by approximately 13%, and the percentage of hyperactivated sperm in the treatment group was significantly 2.5 times higher than that of the diabetic controls. Additionally, testosterone levels were significantly elevated by 27%, further supporting the positive effects on reproductive health. The probiotic supplementation also led to improvements in insulin sensitivity, as evidenced by a 34.12% reduction in homeostasis model assessment index of insulin resistance (HOMA-IR). L. rhamnosus PB01 (DSM 14870) demonstrated potential as an adjunct therapy for managing T1DM-associated complications in the rat model, by improving insulin sensitivity, supporting weight management, and partially restoring diabetes-related fertility impairments, likely through modulation of hormonal pathways. However, further studies are needed to translate the results to humans and refine optimal dosing and supplementation duration for sustained benefits.
本研究调查了补充鼠李糖乳杆菌PB01对1型糖尿病（T1DM）大鼠模型代谢和生殖功能障碍的潜在治疗作用。用鼠李糖乳杆菌PB01（1×10⁹CFU/天）治疗的糖尿病大鼠在代谢和生殖结果方面有显著改善。具体而言，糖尿病引起的体重减轻减轻了约13%，治疗组中过度活化精子的百分比比糖尿病对照组显著高出2.5倍。此外，睾酮水平显著升高了27%，进一步支持了对生殖健康的积极影响。补充益生菌还改善了胰岛素敏感性，胰岛素抵抗稳态模型评估指数（HOMA-IR）降低了34.12%就证明了这一点。鼠李糖乳杆菌PB01（DSM 14870）通过改善胰岛素敏感性、支持体重管理以及部分恢复与糖尿病相关的生育障碍，可能通过调节激素途径，显示出作为辅助疗法治疗大鼠模型中T1DM相关并发症的潜力。然而，需要进一步研究将结果转化到人类身上，并确定最佳剂量和补充持续时间以获得持续益处。
