Chronopoulos Julia, Crespo Maria, Chavakis Triantafyllos
Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany.
Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany; Paul Langerhans Institute Dresden of the Helmholtz Center Munich, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Cancer Cell. 2025 Aug 11;43(8):1394-1396. doi: 10.1016/j.ccell.2025.06.010. Epub 2025 Jul 3.
Two articles in Immunity and Cancer Cell describe that bladder cancer immunotherapy with Bacillus Calmette-Guerin (BCG) alone or in combination with β-glucan, another agonist of trained immunity (TRIM), involves reprogramming of bone marrow (BM) hematopoiesis. These findings provide additional evidence of the therapeutic potential of BM-mediated TRIM against cancer.
《免疫》和《癌细胞》杂志上的两篇文章指出，单独使用卡介苗（BCG）或与另一种训练免疫（TRIM）激动剂β-葡聚糖联合进行膀胱癌免疫治疗，涉及骨髓（BM）造血的重编程。这些发现为BM介导的TRIM治疗癌症的潜力提供了更多证据。
