Kaplan S S, Szulman A E, Surti U
Am J Obstet Gynecol. 1985 Nov 15;153(6):703-7. doi: 10.1016/s0002-9378(85)80263-5.
The effect of fluids from both complete and partial hydatidiform moles on blood coagulation was determined. Coagulation was evaluated with use of the one-stage prothrombin time and the activated partial thromboplastin time. These studies demonstrated that the fluids shortened the activated partial thromboplastin time but not the prothrombin time. The use of plasmas deficient in factors V, VIII, IX, and X as substrate showed that the fluids shortened the activated partial thromboplastin time in the presence of plasmas deficient in factors VIII and IX but had no effect on the activated partial thromboplastin time in the presence of plasmas deficient in factors V and X. These data suggest that hydatidiform mole fluids possess procoagulant activity and that the activation of blood coagulation takes place at the level of factor X. These findings may have relevance to the placental and decidual focal necrosis seen in molar pregnancies, especially those of the complete variety.
测定了完全性和部分性葡萄胎的液体对血液凝固的影响。使用一期凝血酶原时间和活化部分凝血活酶时间来评估凝血情况。这些研究表明，这些液体缩短了活化部分凝血活酶时间，但未缩短凝血酶原时间。使用缺乏因子V、VIII、IX和X的血浆作为底物表明，这些液体在缺乏因子VIII和IX的血浆存在时缩短了活化部分凝血活酶时间，但在缺乏因子V和X的血浆存在时对活化部分凝血活酶时间没有影响。这些数据表明，葡萄胎液体具有促凝活性，并且血液凝固的激活发生在因子X水平。这些发现可能与葡萄胎妊娠中所见的胎盘和蜕膜局灶性坏死有关，尤其是完全性葡萄胎妊娠。
