Department of Toxicology and Food Safety, Institute of Rural Health, Lublin, Poland.
Department for Women's Health, Institute of Rural Health, Lublin, Poland.
Ann Agric Environ Med. 2021 Jun 14;28(2):326-330. doi: 10.26444/aaem/135529. Epub 2021 Apr 13.
Estrogen deficiency found in postmenopausal women may lead to disturbances in the balance of bone metabolism. Study of the influence of estradiol on markers of bone turnover may help to understand the mechanisms of bone metabolism and to monitor osteoporosis therapy in postmenopausal women at high risk of fractures. The aim of the study was evaluation of the effect of estradiol on the basic markers of bone turnover in postmenopausal women.
The study was conducted in a group of 92 postmenopausal women, divided into two groups: Gr-1 with low estradiol levels ≤ 10 pg/ml and Gr-2 with reference estradiol levels ≥ 25 pg/ml). Basic markers of bone turnover were examined: Ctx (C-terminal cross-linked telopeptide of type I collagen alpha chain) and OC (osteocalcin); pro-resorptive cytokines: IL-6 and TNF-α; vitamin 25(OH)D3 and lipid profile. Women was also analyzed according to demographic and clinical data.
A positive relationship was found between estradiol and the main bone formation marker - OC (p = 0.041, r = 0.213) and IL-6, TNF-α (p = 0.007, r = 0.281 and p = 0.018, r = 0.246, respectivly, but only in the group with a reference hormone level. Moreover, the main markers of bone turnover: Ctx and OC showed a mutual positive correlation (p = 0.013; r = 0.257) in women with reference estradiol levels. Relationships between markers of bone remodeling, pro-resorptive cytokines and vitamin D3 depending on the level of estradiol showed no statistically significant correlation.
The study showed that only in women with the reference estradiol level (≥ 25 pg/ml) were the bone formation and resorption processes balanced.
绝经后女性体内雌激素缺乏可能导致骨代谢失衡。研究雌二醇对骨转换标志物的影响有助于了解骨代谢机制，并监测绝经后骨折高风险妇女的骨质疏松症治疗。本研究旨在评估雌二醇对绝经后妇女基本骨转换标志物的影响。
该研究纳入了 92 名绝经后妇女，分为两组：Gr-1 组雌二醇水平较低（≤ 10 pg/ml），Gr-2 组雌二醇水平正常（≥ 25 pg/ml）。检测了基本的骨转换标志物：CTX（I 型胶原 α 链 C 端交联肽）和 OC（骨钙素）；促吸收细胞因子：IL-6 和 TNF-α；维生素 25（OH）D3 和血脂谱。还根据人口统计学和临床数据对女性进行了分析。
发现雌二醇与主要骨形成标志物 - OC 呈正相关（p = 0.041，r = 0.213）和 IL-6、TNF-α（p = 0.007，r = 0.281 和 p = 0.018，r = 0.246，分别，但仅在参考激素水平组中。此外，主要骨转换标志物：CTX 和 OC 在参考雌二醇水平的女性中呈正相关（p = 0.013；r = 0.257）。骨重建标志物、促吸收细胞因子和维生素 D3 之间的关系与雌二醇水平无关，无统计学显著相关性。
本研究表明，只有在参考雌二醇水平（≥ 25 pg/ml）的女性中，骨形成和吸收过程才平衡。
