Dzielak D J, Norman R A
Am J Physiol. 1985 Nov;249(5 Pt 2):H945-9. doi: 10.1152/ajpheart.1985.249.5.H945.
The effect of renal denervation on the onset and maintenance of mineralocorticoid-salt [deoxycorticosterone (DOC)-salt] hypertension was determined. A unilateral right nephrectomy was performed on all rats. Rats were divided into renal-denervated and sham-operated groups. All rats received 10 mg/wk of DOC pivalate and 0.9% saline to drink ad libitum. Renal denervation was repeated at 3-wk intervals to prevent renal nerve regeneration. Renal denervation had no effect on the onset or maintenance of DOC-salt hypertension. Hypertension developed over the same time course in both the renal-denervated and sham-operated rats regardless of the time frame of unilateral nephrectomy and renal denervation. Tail-cuff pressure measurements reached plateau levels of 187 +/- 5.7 mmHg in sham-operated and 183 +/- 4.6 mmHg in renal-denervated rats after 4 wk of DOC-salt administration. Mean arterial pressure averaged 197 +/- 10.3 mmHg in sham-operated and 200 +/- 7.9 mmHg in renal-denervated rats after 8 wk of treatment. Intact renal nerves are not necessary for the development or maintenance of DOC-salt hypertension in rats.
确定了肾去神经支配对盐皮质激素-盐（脱氧皮质酮-盐，DOC-盐）高血压发病及维持的影响。对所有大鼠实施右侧单侧肾切除术。将大鼠分为肾去神经支配组和假手术组。所有大鼠每周接受10mg的特戊酸脱氧皮质酮，并随意饮用0.9%的盐水。每隔3周重复进行肾去神经支配以防止肾神经再生。肾去神经支配对DOC-盐高血压的发病或维持没有影响。无论单侧肾切除术和肾去神经支配的时间框架如何，肾去神经支配大鼠和假手术大鼠的高血压在相同的时间进程中发展。给予DOC-盐4周后，假手术大鼠的尾袖带压力测量达到平台期水平，为187±5.7mmHg，肾去神经支配大鼠为183±4.6mmHg。治疗8周后，假手术大鼠的平均动脉压平均为197±10.3mmHg，肾去神经支配大鼠为200±7.9mmHg。完整的肾神经对于大鼠DOC-盐高血压的发生或维持并非必需。
