Norman R A, Dzielak D J
Am J Physiol. 1982 Aug;243(2):H284-8. doi: 10.1152/ajpheart.1982.243.2.H284.
Renal denervation has been reported to delay development of hypertension in Okamoto spontaneously hypertensive rats (SHR) but to have no effect on the final hypertensive state. However, functional reinnervation begins to occur about 1 mo after renal denervation. The arterial pressure of SHR undergoing repeated bilateral renal denervations at the age of 4, 7, 10, 13, and 16 wk was compared with that in sham-operated SHR. In addition, the effect of successive renal denervations at 4, 7, and 10 wk of age in Wistar-Kyoto (WKY) control rats was determined. Both indirect measurement of pressure by the tail-cuff technique and mean arterial pressure (MAP) measurement indicated that renal denervation prevents full expression of hypertension in SHR. MAP in 19-wk-old renal-denervation SHR averaged 159 +/- 5.1 mmHg (SE) vs. 178 +/-0 4.2 mmHg in sham-operated SHR. Renal denervation had no effect on arterial pressure of WKY rats. Renal norepinephrine content in the renal-denervated WKY rats and SHR was less than 20% of that in the sham-operated groups. Successive bilateral renal denervations every 3 wk blocks 30-40% of the expected progressive elevation of arterial pressure in aging SHR.
据报道，肾去神经支配可延缓冈本自发性高血压大鼠（SHR）高血压的发展，但对最终的高血压状态无影响。然而，功能性再神经支配在肾去神经支配后约1个月开始出现。将4、7、10、13和16周龄时接受反复双侧肾去神经支配的SHR的动脉血压与假手术SHR的动脉血压进行比较。此外，还确定了在Wistar-Kyoto（WKY）对照大鼠4、7和10周龄时连续进行肾去神经支配的效果。通过尾套技术间接测量血压和测量平均动脉压（MAP）均表明，肾去神经支配可阻止SHR高血压的完全表现。19周龄肾去神经支配的SHR的MAP平均为159±5.1 mmHg（标准误），而假手术SHR为178±4.2 mmHg。肾去神经支配对WKY大鼠的动脉血压无影响。肾去神经支配的WKY大鼠和SHR的肾去甲肾上腺素含量低于假手术组的20%。每3周连续进行双侧肾去神经支配可阻断衰老SHR预期动脉血压渐进性升高的30%-40%。
