Li Jian, Li Changqing, Tao Lin, Wang Lei, Wang Gang, Kong Youqi, Zhou Lichun
Beijing Chao Yang Hospital, Department of Neurology, Capital University of Medical Sciences, Beijing, China.
Department of Neurology, Yuncheng City Central Hospital, Shanxi, China.
BMC Cardiovasc Disord. 2025 Jul 5;25(1):489. doi: 10.1186/s12872-025-04779-5.
Cardiovascular diseases (CVDs) has been identified as a primary cause of mortality on a global scale. The present study was conducted with the objective of investigating the association between serum vitamin E levels and the risk of developing CVDs, with the aim of identifying potential risk thresholds.
Using National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2002, we included 3,516 adult participants. Serum vitamin E concentrations were measured by high-performance liquid chromatography, and CVDs status was assessed through medical questionnaires and interviews. Multivariable logistic regression and segmented linear models analyzed the association between serum vitamin E and CVDs risk.
A J-shaped relationship between serum vitamin E and CVDs risk was observed. Segmented linear regression revealed a nonlinear association between vitamin E concentration and CVDs incidence. At low concentrations (below 85.24 µg/dL), although the OR suggested a potential protective trend (OR: 0.968, 95% CI: 0.926-1.011), this association did not reach statistical significance (P = 0.1422), indicating no conclusive evidence of risk reduction. Beyond this threshold, CVDs risk significantly increased (OR: 1.056, 95% CI: 1.003-1.112, P = 0.0377). Notably, the high-concentration group demonstrated a substantially elevated CVDs risk, with a 4.18-fold increase (OR: 4.18, 95% CI: 2.84-6.16, P < 0.0001).
Maintaining serum vitamin E levels within an optimal range is crucial for reducing CVDs risk. The study reveals the complex nonlinear relationship between vitamin E concentration and disease risk, providing important insights for clinical practice and public health strategies.
心血管疾病（CVDs）已被确定为全球范围内的主要死亡原因。本研究旨在调查血清维生素E水平与发生心血管疾病风险之间的关联，以确定潜在的风险阈值。
利用1999年至2002年的美国国家健康与营养检查调查（NHANES）数据，我们纳入了3516名成年参与者。血清维生素E浓度通过高效液相色谱法测量，心血管疾病状况通过医学问卷和访谈进行评估。多变量逻辑回归和分段线性模型分析了血清维生素E与心血管疾病风险之间的关联。
观察到血清维生素E与心血管疾病风险之间呈J形关系。分段线性回归显示维生素E浓度与心血管疾病发病率之间存在非线性关联。在低浓度（低于85.24μg/dL）时，尽管比值比显示出潜在的保护趋势（比值比：0.968，95%置信区间：0.926 - 1.011），但这种关联未达到统计学显著性（P = 0.1422），表明没有确凿的风险降低证据。超过这个阈值，心血管疾病风险显著增加（比值比：1.056，95%置信区间：1.003 - 1.112，P = 0.0377）。值得注意的是，高浓度组的心血管疾病风险大幅升高，增加了4.18倍（比值比：4.18，95%置信区间：2.84 - 6.16，P < 0.0001）。
将血清维生素E水平维持在最佳范围内对于降低心血管疾病风险至关重要。该研究揭示了维生素E浓度与疾病风险之间复杂的非线性关系，为临床实践和公共卫生策略提供了重要见解。
