Cao Jing, Su Yingjie, Xiao Yijia, Zhao Sue, Yang Hongzhong
Medical Insurance Department, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, 410004 Changsha, Hunan, China.
Department of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, 410004 Changsha, Hunan, China.
Int J Vitam Nutr Res. 2025 Feb 13;95(1):26882. doi: 10.31083/IJVNR26882.
Remnant cholesterol (RC) is a risk factor for the development of atherosclerosis. Vitamin E has antioxidant properties, making it a potentially effective management tool for preventing cardiovascular disease (CVD). However, the relationship between vitamin E intake and RC remains unclear.
We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) Survey 2007-2020. 11,585 participants (aged ≥20, 48% male) were included. Information on vitamin E intake (dietary vitamin E intake and total vitamin E intake) was collected. RC was defined as serum total cholesterol minus high-density lipoprotein and low-density lipoprotein cholesterol. Survey-weighted linear regression models and a restricted cubic spline (RCS) were used to test the relationship between vitamin E intake and RC. Subgroup analyses and interaction tests were also performed to verify the robustness of the results.
After adjusting for all potential confounders (demographics, socioeconomic status, lifestyle, diet, and comorbidities), dietary vitamin E intake was negatively associated with RC (β = -0.21, 95% CI: (-0.29, -0.12), < 0.0001), and this negative association was also present between total vitamin E intake and RC (β = -0.12, 95% CI: (-0.18, -0.06), < 0.0001). The RCS analysis revealed a nonlinear negative association between vitamin E intake and RC. The negative correlation existed in different subgroups, with no interaction except for the "use of vitamin E supplements" subgroup.
Vitamin E intake showed a protective association with RC. The results suggest that increasing dietary vitamin E intake may help reduce RC levels and CVD risk.
残余胆固醇（RC）是动脉粥样硬化发生发展的危险因素。维生素E具有抗氧化特性，使其成为预防心血管疾病（CVD）的潜在有效管理工具。然而，维生素E摄入量与RC之间的关系仍不明确。
我们使用2007 - 2020年美国国家健康与营养检查调查（NHANES）的数据进行了一项横断面研究。纳入了11,585名参与者（年龄≥20岁，48%为男性）。收集了维生素E摄入量（膳食维生素E摄入量和总维生素E摄入量）的信息。RC定义为血清总胆固醇减去高密度脂蛋白和低密度脂蛋白胆固醇。使用调查加权线性回归模型和受限立方样条（RCS）来检验维生素E摄入量与RC之间的关系。还进行了亚组分析和交互作用检验以验证结果的稳健性。
在调整所有潜在混杂因素（人口统计学、社会经济地位、生活方式、饮食和合并症）后，膳食维生素E摄入量与RC呈负相关（β = -0.21，95%置信区间：(-0.29, -0.12)，P < 0.0001），总维生素E摄入量与RC之间也存在这种负相关（β = -0.12，95%置信区间：(-0.18, -0.06)，P < 0.0001）。RCS分析显示维生素E摄入量与RC之间存在非线性负相关。不同亚组中均存在负相关，除“使用维生素E补充剂”亚组外无交互作用。
维生素E摄入量与RC呈保护性关联。结果表明增加膳食维生素E摄入量可能有助于降低RC水平和心血管疾病风险。
