Leicht P, Wisborg T, Chraemmer-Jørgensen B
Anesth Analg. 1985 Dec;64(12):1193-6.
One hundred otherwise healthy children undergoing tonsillectomy were investigated in a double-blind study to examine the effect of intravenous lidocaine in preventing laryngospasm upon extubation. The children were anesthetized with N2O-O2-halothane and orally intubated. They were randomly given lidocaine, 1.5 mg/kg, or saline intravenously prior to extubation, which took place at the same depth of anesthesia, namely when there were signs of swallowing activity. Eleven children (2%) in each group of 50 developed laryngospasm. From our findings it is concluded that lidocaine, 1.5 mg/kg, does not prevent laryngospasm upon extubation when extubation is carried out at the start of swallowing activity.
在一项双盲研究中，对100名即将接受扁桃体切除术的健康儿童进行了调查，以研究静脉注射利多卡因在预防拔管时喉痉挛方面的效果。这些儿童采用N2O-O2-氟烷麻醉并经口插管。在拔管前，他们被随机静脉注射1.5mg/kg利多卡因或生理盐水，拔管在相同麻醉深度下进行，即出现吞咽活动迹象时。每组50名儿童中有11名（2%）发生了喉痉挛。根据我们的研究结果得出结论，当在吞咽活动开始时进行拔管时，1.5mg/kg的利多卡因不能预防拔管时的喉痉挛。
