Gefke K, Andersen L W, Friesel E
Acta Anaesthesiol Scand. 1983 Apr;27(2):111-2. doi: 10.1111/j.1399-6576.1983.tb01917.x.
The preventive effect of lidocaine against coughing in the recovery period after general anaesthesia was observed. The study was carried out as a double-blind sequential trial. At the same time the incidence of laryngospasm was registered. Lidocaine or placebo was given intravenously just before extubation. Nineteen patients for tonsillectomy, all of them over the age of 15, randomly received a 2% solution of lidocaine 2 mg/kg body weight or placebo (saline) 2 min prior to expected extubation. We found that lidocaine in this dose given prophylactically just before extubation was able to inhibit and prevent coughing in the recovery period after general anaesthesia. None of the patients included in this study got laryngospasm, and none of the patients developed serious side-effects.
观察了利多卡因对全身麻醉恢复期咳嗽的预防作用。该研究作为双盲序贯试验进行。同时记录喉痉挛的发生率。在拔管前即刻静脉注射利多卡因或安慰剂。19例扁桃体切除术患者，均为15岁以上，在预计拔管前2分钟随机接受2%利多卡因溶液2mg/kg体重或安慰剂（生理盐水）。我们发现，在拔管前预防性给予该剂量的利多卡因能够抑制和预防全身麻醉恢复期的咳嗽。本研究纳入的患者均未发生喉痉挛，也没有患者出现严重副作用。
