Liu Pidong, Sun Yanwei
Department of Neurophysiology, Zibo Central Hospital, Zibo, PR China.
Department of Burns and Plastic Surgery, Zibo Central Hospital, Zibo, PR China.
Sci Prog. 2025 Jul-Sep;108(3):368504251357509. doi: 10.1177/00368504251357509. Epub 2025 Jul 7.
Neurofibromas are benign peripheral nerve sheath tumors that occur in individuals with neurofibromatosis type 1. In pediatric patients, giant neurofibromas pose significant management challenges due to their large size and potential to cause functional impairments. Given their characteristic radiation resistance, indolent growth, and limited chemosensitivity, surgical intervention is frequently required to alleviate tumor-related symptoms, restore function, and mitigate complications. The two primary surgical difficulties are the high recurrence rates resulting from the infiltrative nature of giant neurofibromas and the risk of massive intraoperative hemorrhage. This case report details the surgical management of a pediatric giant neurofibroma, highlighting the multidisciplinary strategy and operative techniques employed to achieve optimal results.
神经纤维瘤是发生于1型神经纤维瘤病患者的良性周围神经鞘瘤。在儿科患者中,巨大神经纤维瘤因其体积大及可能导致功能障碍而带来重大的治疗挑战。鉴于其具有抗辐射、生长缓慢和化疗敏感性有限的特点,常常需要手术干预以缓解肿瘤相关症状、恢复功能并减轻并发症。两个主要的手术难点是巨大神经纤维瘤的浸润性导致的高复发率以及术中大出血的风险。本病例报告详细介绍了一名儿科巨大神经纤维瘤的手术治疗情况,突出了为取得最佳效果而采用的多学科策略和手术技术。