Boosinger T R, Thacker H L, Armstrong C H
Am J Vet Res. 1985 Oct;46(10):2152-6.
At 4 days of age, 7 gnotobiotic pigs were orally inoculated with broth cultures of both Campylobacter sputorum subsp mucosalis (CSM) and Campylobacter hyointestinalis (CH). One pig was killed and evaluated each week for 7 weeks. Forty-eight hours after inoculation, CH and CSM were recovered from the feces of the pigs; thereafter, only CH was recovered. Organisms morphologically typical of Campylobacter sp were observed on the mucosal surface and on the crypt epithelial cells of the ileum, cecum, and colon from post-inoculation weeks (PIW) 2 through 7. Bacteria were clustered around the surface opening of goblet cells in pigs at PIW 6 and 7. Crypt epithelial cell proliferation and intracellular bacteria were not seen, except in 1 pig (killed at PIW 7) in which intracellular bacteria were seen only in the cecum. Therefore, CSM and CH did not induce porcine proliferative enteritis in gnotobiotic pigs.
4日龄时，给7头无菌猪口服接种了黏膜螺旋体弯曲杆菌（CSM）和猪肠弯曲杆菌（CH）的肉汤培养物。每周处死1头猪并进行评估，持续7周。接种后48小时，从猪的粪便中分离出CH和CSM；此后，仅分离出CH。在接种后第2周至第7周，在回肠、盲肠和结肠的黏膜表面以及隐窝上皮细胞上观察到形态典型的弯曲杆菌属微生物。在接种后第6周和第7周的猪中，细菌聚集在杯状细胞的表面开口周围。除1头猪（在接种后第7周处死）的盲肠中仅见细胞内细菌外，未观察到隐窝上皮细胞增殖和细胞内细菌。因此，CSM和CH未在无菌猪中诱发猪增生性肠炎。
