Lomax L G, Glock R D, Harris D L, Hogan J E
Am J Vet Res. 1982 Sep;43(9):1622-30.
The hypotheses that porcine proliferative enteritis is an infectious disease and that Campylobacter sputorum subsp mucosalis (CSM) is involved in the development of this disease were experimentally tested. Three experiments were conducted with 10-week-old, cesarean-derived colostrum-deprived pigs. Of 22 pigs given homogenized mucosal scrapings (crude inocula) intragastrically, 15 had gross and/or microscopic lesions of proliferative enteritis. Of 10 pigs inoculated with cultures of both CSM and Salmonella cholerae-suis, 2 had evidence of proliferative enteritis. The 4 pigs treated with S cholerae suis only had diffuse fibrinous gastroenteritis without evidence of mucosal proliferation. Proliferative enteritis was produced in 1 of 5 pigs inoculated with pure cultures of CSM. Proliferative lesions in the intestine were characterized by the proliferation of immature crypt epithelial cells. Affected cells contained variable numbers of curved, intracytoplasmic Campylobacter sp organisms. The CSM organism was isolated from the intestinal mucosa of 8 pigs treated with either crude inocula or cultures of CSM.
关于猪增生性肠炎是一种传染病以及唾液弯曲菌黏膜亚种（CSM）参与该病发生发展的假说，已通过实验进行了验证。对10周龄、剖腹产获得且未摄入初乳的仔猪进行了三项实验。给22头仔猪经胃内给予匀浆化的黏膜刮片（粗制接种物），其中15头出现了增生性肠炎的大体和/或微观病变。给10头仔猪接种CSM和猪霍乱沙门氏菌的培养物，其中2头有增生性肠炎的迹象。仅用猪霍乱沙门氏菌治疗的4头仔猪出现弥漫性纤维蛋白性胃肠炎，无黏膜增生迹象。接种CSM纯培养物的5头仔猪中有1头出现了增生性肠炎。肠道中的增生性病变以未成熟隐窝上皮细胞的增生为特征。受影响的细胞含有数量不等的弯曲的胞质内弯曲菌属微生物。从用粗制接种物或CSM培养物处理的8头仔猪的肠黏膜中分离出了CSM菌。
