Kway Venance Basil, Rojas José Enrique Calacuayo, Cuevas Josué Sidonio Rodríguez, Moreno Ursula Medina, Juárez José Sergio Camacho, González Jorge Francisco Ayala, Larraga Karla Krebs, Martinez Ilse Veronica Castro, Reyther Roberto Arturo Castillo, Moscoso Antonio Gordillo
Department of Obstetrics and Gynecology, Central Hospital Dr. Ignacio Morones Prieto, San Luis Potosí 78290, Mexico.
Department of Biomedical Engineering, Faculty of Science, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78290, Mexico.
Matern Fetal Med. 2025 Jan;7(1):3-8. doi: 10.1097/FM9.0000000000000255. Epub 2024 Nov 7.
To validate the hematocrit percentage drop cutoff points for blood loss in patients with postpartum hemorrhage (PPH) using the automated gravimetric method.
A prospective cohort study was conducted from January 2023 to July 2023, in which 107 patients 18 years of age and above were scheduled for elective cesarean with obstetrical indications. We excluded cases with difficulty quantifying blood loss, those with incomplete data, and those of patients who did not consent to participate. Blood loss was measured by an automated gravimetric system integrated into a suction blood collector and surgical gauze weighing systems to automatically sum up blood loss immediately after hysterectomy and fetal delivery. The percentage drop in hematocrit was determined by subtracting the 8-hour postsurgical from presurgical hematocrit, divided by presurgical hematocrit. We performed the Pearson correlation test, and the receiver operating characteristic curve was used to determine cutoff points, their sensitivity, and their specificity. The κ index was used to determine the diagnostic agreement between the two methods.
A positive correlation was observed between the volume of blood loss and the percentage drop in hematocrit, with a Pearson correlation index of 0.70 and < 0.0001. A 14% decrease in hematocrit had an 81.7% agreement rate, with a good κ index of 0.602, a sensitivity of 82.5%, and a specificity of 80.0%. A 10% drop in hemoglobin was sensitive (93.0%) but not very specific (56.0%) for blood loss greater than 1000 mL.
The automated gravimetric method strongly correlates with hematocrit changes, providing an accurate real-time diagnosis of PPH. Additionally, a hematocrit percentage drop can retrospectively indicate significant blood loss, aiding in managing patients at risk for long-term PPH complications.
采用自动重量法验证产后出血(PPH)患者失血时的血细胞比容百分比下降临界值。
于2023年1月至2023年7月进行一项前瞻性队列研究,纳入107例18岁及以上有产科指征行择期剖宫产的患者。我们排除了失血难以量化的病例、数据不完整的病例以及不同意参与的患者。通过集成在吸血收集器和手术纱布称重系统中的自动重量系统测量失血量,以在子宫切除术后和胎儿娩出后立即自动汇总失血量。血细胞比容的下降百分比通过术前血细胞比容减去术后8小时血细胞比容,再除以术前血细胞比容来确定。我们进行了Pearson相关性检验,并使用受试者工作特征曲线来确定临界值、其敏感性和特异性。κ指数用于确定两种方法之间的诊断一致性。
观察到失血量与血细胞比容下降百分比之间呈正相关,Pearson相关指数为0.70,P<0.0001。血细胞比容下降14%时,一致率为81.7%,κ指数为0.602,敏感性为82.5%,特异性为80.0%。血红蛋白下降10%对失血量大于1000 mL时敏感性较高(93.0%)但特异性不强(56.0%)。
自动重量法与血细胞比容变化密切相关,可对产后出血进行准确的实时诊断。此外,血细胞比容百分比下降可回顾性地提示大量失血,有助于管理有产后出血长期并发症风险的患者。