Huang Hui, Wang Qian, Zhang Ruimin, Liu Fang, Niu Yue, Luo Yayong, Wang Junqian, Li Shuang, Tang Zhengchun, Cao Xueying, Wang Xiaolong, Yang Jian, Luo Sha, Deng Weizhu, Zhang Weiguang, Zheng Ying, Wang Yong, Zhang Li, Cai Guangyan, Chen Xiangmei, Dong Zheyi
School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Disease, Key Disciplines of National Administration of Traditional Chinese Medicine (zyyzdxk-2023310), Beijing, China.
Front Endocrinol (Lausanne). 2025 Jun 20;16:1589528. doi: 10.3389/fendo.2025.1589528. eCollection 2025.
UNLABELLED: This study explored the associations between triglyceride glucose (TyG), TyG with body mass index (TyG-BMI), triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio, and metabolic score for insulin resistance (METS-IR) and the effects of dietary acid-base load in patients with chronic kidney disease (CKD). METHODS: A total of 288 patients with CKD were included in this study. Four non-insulin-based insulin resistance (IR) markers were used to assess IR levels in patients with CKD; dietary intake - 24-h dietary recall; and diet-based acidity - potential renal acid load (PRAL), net endogenous acid production (NEAP), and dietary acid load (DAL). Multiple linear regression analysis correlated dietary acid-base load and non-insulin-based IR markers. RESULTS: Spearman's correlation indicated DAL was significantly associated with TyG-BMI (r = 0.251, P < 0.001) and METS-IR (r = 0.274, P < 0.001), but weakly correlated with the TG/HDL-C ratio (r = 0.14, P = 0.018). After adjusting for sex, age, energy, hypertension (HTN), diabetes, and estimated glomerular filtration rate, multiple linear regression analysis showed that DAL was associated with TyG-BMI (β = 0.336; P = 0.008) and METS-IR (β = 0.091; P = 0.007). CONCLUSIONS: Patients with the highest DAL scores had the highest TyG-BMI, TyG, TG/HDL-C ratio, and METS-IR. After adjusting for confounders, there was a significant positive association between DAL and TyG-BMI and METS-IR.
未标注：本研究探讨了甘油三酯葡萄糖（TyG）、TyG与体重指数（TyG-BMI）、甘油三酯与高密度脂蛋白胆固醇比值（TG/HDL-C）以及胰岛素抵抗代谢评分（METS-IR）之间的关联，以及饮食酸碱负荷对慢性肾脏病（CKD）患者的影响。 方法：本研究共纳入288例CKD患者。使用四种非胰岛素抵抗（IR）标志物评估CKD患者的IR水平；饮食摄入量——24小时饮食回顾；以及基于饮食的酸度——潜在肾酸负荷（PRAL）、净内源性酸产生（NEAP）和饮食酸负荷（DAL）。多元线性回归分析将饮食酸碱负荷与非胰岛素抵抗IR标志物相关联。 结果：Spearman相关性分析表明，DAL与TyG-BMI显著相关（r = 0.251，P < 0.001）和METS-IR（r = 0.274，P < 0.001），但与TG/HDL-C比值相关性较弱（r = 0.14，P = 0.018）。在调整性别、年龄、能量、高血压（HTN）、糖尿病和估计肾小球滤过率后，多元线性回归分析显示，DAL与TyG-BMI（β = 0.336；P = 0.008）和METS-IR（β = 0.091；P = 0.007）相关。 结论：DAL评分最高的患者具有最高的TyG-BMI、TyG、TG/HDL-C比值和METS-IR。在调整混杂因素后，DAL与TyG-BMI和METS-IR之间存在显著的正相关。
Front Endocrinol (Lausanne). 2025-6-20
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