Hu Xinying, Han Peng, Liu Yong
Heilongjiang University of Chinese Medicine, Harbin, China.
First Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
J Am Nutr Assoc. 2025 Jan 10:1-11. doi: 10.1080/27697061.2025.2450711.
Diabetes is closely related to hypertension, and insulin resistance-related indices are novel metrics used to evaluate the risk of diabetes and cardiovascular diseases. This study aims to explore the relationships between the TyG index, METS-IR, TG/HDL-C, and HOMA-IR with hypertension.
Data from the NHANES spanning ten consecutive survey cycles from 1998 to 2018 were utilized, focusing on adults with complete blood pressure data and comprehensive information for calculating the TyG index, METS-IR, TG/HDL-C, and HOMA-IR. A multivariable logistic regression model was employed to examine the relationship between insulin resistance indices and hypertension as well as blood pressure levels, while subgroup analyses were conducted to explore potential influencing factors. RCS curves were used to describe both linear and non-linear relationships.
This NHANES-based study included 16,062 adults. Regardless of the adjustment for covariates, significant associations were found between the TyG index, METS-IR, TG/HDL-C, HOMA-IR and hypertension risk. The ROC curve demonstrated the stability of the TyG index, METS-IR, TG/HDL-C, and HOMA-IR in predicting hypertension risk. The RCS curves uncovered a linear relationship between the TyG index, METS-IR, and hypertension, whereas TG/HDL-C and HOMA-IR exhibited a non-linear association with hypertension. Subgroup analyses indicated that smoking and diabetes may influence the relationship between insulin resistance-related indices and hypertension.
Elevated levels of the insulin resistance indices TyG index, METS-IR, TG/HDL-C, and HOMA-IR are closely associated with hypertension risk. These indices can serve as effective markers for monitoring hypertension risk in clinical practice. However, larger-scale prospective cohort studies are needed to validate these findings and further explore the clinical application potential of the TyG index, METS-IR, TG/HDL-C, and HOMA-IR as tools for cardiovascular risk assessment. Such studies will help elucidate the specific causal relationships between these insulin resistance-related indices and hypertension and advance their practical application in clinical settings.
糖尿病与高血压密切相关，胰岛素抵抗相关指标是用于评估糖尿病和心血管疾病风险的新指标。本研究旨在探讨TyG指数、METS-IR、TG/HDL-C和HOMA-IR与高血压之间的关系。
利用1998年至2018年连续十个调查周期的美国国家健康与营养检查调查（NHANES）数据，重点关注有完整血压数据以及可用于计算TyG指数、METS-IR、TG/HDL-C和HOMA-IR的综合信息的成年人。采用多变量逻辑回归模型来检验胰岛素抵抗指标与高血压以及血压水平之间的关系，同时进行亚组分析以探索潜在影响因素。采用限制立方样条（RCS）曲线来描述线性和非线性关系。
这项基于NHANES的研究纳入了16062名成年人。无论对协变量进行何种调整，均发现TyG指数、METS-IR、TG/HDL-C、HOMA-IR与高血压风险之间存在显著关联。ROC曲线表明TyG指数、METS-IR、TG/HDL-C和HOMA-IR在预测高血压风险方面具有稳定性。RCS曲线揭示了TyG指数、METS-IR与高血压之间的线性关系，而TG/HDL-C和HOMA-IR与高血压呈非线性关联。亚组分析表明，吸烟和糖尿病可能会影响胰岛素抵抗相关指标与高血压之间的关系。
胰岛素抵抗指标TyG指数、METS-IR、TG/HDL-C和HOMA-IR水平升高与高血压风险密切相关。这些指标可作为临床实践中监测高血压风险的有效标志物。然而，需要更大规模的前瞻性队列研究来验证这些发现，并进一步探索TyG指数、METS-IR、TG/HDL-C和HOMA-IR作为心血管风险评估工具的临床应用潜力。此类研究将有助于阐明这些胰岛素抵抗相关指标与高血压之间的具体因果关系，并推动它们在临床环境中的实际应用。
