Psychological stress is a well-established inhibitor of wound healing, yet its specific impact on scar treatment efficacy remains underexplored. Given the significance of collagen synthesis in wound healing and various advanced scar treatments, an investigation into the impact of psychological stress on these processes is warranted. This review examines the biological mechanisms of wound healing and collagen formation, focusing on how psychological stress disrupts these pathways and impacts scar treatment outcomes. Current literature indicates that psychological stress impairs collagen production and reduces the efficacy of scar treatments. These findings underscore the importance of integrating stress management into scar treatment protocols and highlight the need for further research into combined physiological and psychological approaches to optimize healing.