Ha Heejun, Shin Heeseon, Min Sukhyun, Sutopo Natasha Christabella, Yerkesh Khamit, Jung Eunsun, Song Minkyung, Cho Jae Youl, Lee Jongsung
Molecular Dermatology Laboratory, Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Republic of Korea.
Department of Biocosmetics, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Republic of Korea.
J Ginseng Res. 2025 Jul;49(4):366-375. doi: 10.1016/j.jgr.2025.04.004. Epub 2025 Apr 15.
The circadian rhythm, a biological system all living organisms possess, has become increasingly important as sleep patterns become more irregular. Circadian rhythms affect various cell types (fibroblasts, fat cells, muscles, etc.) and organs (the liver, pancreas, gut, etc.). This review focuses on the effects of the circadian rhythm on skin physiology. Under normal conditions, the circadian rhythm is involved in maintaining skin health, including DNA repair and wound healing. Disrupted circadian rhythm can cause skin disorders, including hyperpigmentation, melanoma, skin aging, sunburn, impaired wound healing, and an abnormal skin barrier. Furthermore, the effects of ginsenosides, the primary bioactive component of , were examined on recovery from skin disorders associated with circadian rhythm disruptions. Therefore, this review explains the relationship between skin physiology and circadian rhythm and suggests the potential of ginseng as a treatment for circadian rhythm-mediated skin disorders.
昼夜节律是所有生物都拥有的一种生物系统，随着睡眠模式变得越来越不规律，它变得越来越重要。昼夜节律会影响各种细胞类型（成纤维细胞、脂肪细胞、肌肉等）和器官（肝脏、胰腺、肠道等）。本综述聚焦于昼夜节律对皮肤生理的影响。在正常情况下，昼夜节律参与维持皮肤健康，包括DNA修复和伤口愈合。昼夜节律紊乱会导致皮肤疾病，包括色素沉着、黑色素瘤、皮肤老化、晒伤、伤口愈合受损以及皮肤屏障异常。此外，还研究了人参主要生物活性成分人参皂苷对与昼夜节律紊乱相关的皮肤疾病恢复的影响。因此，本综述解释了皮肤生理与昼夜节律之间的关系，并提出人参作为治疗昼夜节律介导的皮肤疾病的潜力。
