Cong Lele, Ma Jinli, Zhang Yundong, Zhou Yifa, Cong Xianling, Hao Miao
Department of Dermatology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
Key Laboratory of Lymphatic Surgery Jilin Province, Jilin Engineering Laboratory for Lymphatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
J Ginseng Res. 2023 Sep;47(5):605-614. doi: 10.1016/j.jgr.2023.04.005. Epub 2023 May 4.
Ginsenosides are bioactive components of Panax ginseng with many functions such as anti-aging, anti-oxidation, anti-inflammatory, anti-fatigue, and anti-tumor. Ginsenosides are categorized into dammarane, oleanene, and ocotillol type tricyclic triterpenoids based on the aglycon structure. Based on the sugar moiety linked to C-3, C-20, and C-6, C-20, dammarane type was divided into protopanaxadiol (PPD) and protopanaxatriol (PPT). The effects of ginsenosides on skin disorders are noteworthy. They play anti-aging roles by enhancing immune function, resisting melanin formation, inhibiting oxidation, and elevating the concentration of collagen and hyaluronic acid. Thus, ginsenosides have previously been widely used to resist skin diseases and aging. This review details the role of ginsenosides in the anti-skin aging process from mechanisms and experimental research.
人参皂苷是人参的生物活性成分，具有多种功能，如抗衰老、抗氧化、抗炎、抗疲劳和抗肿瘤。根据苷元结构，人参皂苷可分为达玛烷型、齐墩果烷型和奥克梯隆型三环三萜类化合物。根据连接在C-3、C-20以及C-6、C-20上的糖部分，达玛烷型又分为原人参二醇（PPD）和原人参三醇（PPT）。人参皂苷对皮肤疾病的作用值得关注。它们通过增强免疫功能、抵抗黑色素形成、抑制氧化以及提高胶原蛋白和透明质酸的浓度来发挥抗衰老作用。因此，人参皂苷此前已被广泛用于抵抗皮肤疾病和衰老。本文综述从作用机制和实验研究方面详细阐述了人参皂苷在抗皮肤衰老过程中的作用。
