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Sonographic evidence of hepatic steatosis is highly prevalent in at-risk children under 4 years of age.

作者信息

Glenn Alexandra O, Green Shannon, Mouzaki Marialena, Trout Andrew T

机构信息

Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Department of Radiology, Kaiser Permanente San Diego, Southern California Permanente Medical Group, San Diego, California, USA.

出版信息

J Pediatr Gastroenterol Nutr. 2025 Sep;81(3):679-682. doi: 10.1002/jpn3.70142. Epub 2025 Jul 7.

DOI:10.1002/jpn3.70142
PMID:40621652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12408943/
Abstract
摘要

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Sonographic evidence of hepatic steatosis is highly prevalent in at-risk children under 4 years of age.肝脏脂肪变性的超声证据在4岁以下的高危儿童中非常普遍。
J Pediatr Gastroenterol Nutr. 2025 Sep;81(3):679-682. doi: 10.1002/jpn3.70142. Epub 2025 Jul 7.
2
Nonalcoholic Fatty Liver非酒精性脂肪肝
3
Ultrasound hepatorenal index for the diagnosis of steatosis in patients with type 2 diabetes: a prospective validation study.超声肝肾指数用于诊断2型糖尿病患者肝脂肪变性：一项前瞻性验证研究。
Eur Radiol. 2025 Jun 25. doi: 10.1007/s00330-025-11774-z.
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Breaking boundaries: Unraveling metabolic dysfunction-associated steatotic liver disease in children of India and Canada.突破界限：解析印度和加拿大儿童中与代谢功能障碍相关的脂肪性肝病
Can Liver J. 2024 Feb 26;7(3):327-337. doi: 10.3138/canlivj-2023-0023. eCollection 2024 Aug.
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Assessment of hepatic steatosis in children with metabolic dysfunction-associated steatotic liver disease using ultrasound derived fat fraction: first large-scale clinical evaluation.利用超声衍生脂肪分数评估代谢功能障碍相关脂肪性肝病患儿的肝脂肪变性：首次大规模临床评估
Quant Imaging Med Surg. 2025 Jun 6;15(6):5582-5592. doi: 10.21037/qims-24-2393. Epub 2025 May 30.
6
Comparable glucagon-stimulated amino acid suppression in individuals with and without hepatic steatosis or steatohepatitis.在有或无肝脂肪变性或脂肪性肝炎的个体中，胰高血糖素刺激的氨基酸抑制作用相当。
Am J Physiol Endocrinol Metab. 2024 Dec 1;327(6):E679-E685. doi: 10.1152/ajpendo.00187.2024. Epub 2024 Sep 18.
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Clin Gastroenterol Hepatol. 2025 Jun 27. doi: 10.1016/j.cgh.2025.06.011.
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MASLD, hepatic steatosis and fibrosis are associated with the prevalence of chronic kidney disease and retinopathy in adults with type 1 diabetes mellitus.MASLD、肝脂肪变性和纤维化与 1 型糖尿病成人慢性肾脏病和视网膜病变的患病率相关。
Diabetes Metab. 2024 Jan;50(1):101497. doi: 10.1016/j.diabet.2023.101497. Epub 2023 Nov 20.

本文引用的文献

1
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A State-of-the-Art Review.代谢功能障碍相关脂肪性肝病（MASLD）：最新综述
J Obes Metab Syndr. 2023 Sep 30;32(3):197-213. doi: 10.7570/jomes23052. Epub 2023 Sep 13.
2
Prevalence of incidental sonographic findings of hepatic steatosis in children under 4 years of age.4岁以下儿童肝脏脂肪变性超声偶然发现的患病率。
Pediatr Radiol. 2023 Oct;53(11):2221-2228. doi: 10.1007/s00247-023-05729-z. Epub 2023 Aug 11.
3
Diagnostic performance of ultrasound hepatorenal index for the diagnosis of hepatic steatosis in children.超声肝肾指数诊断儿童肝脂肪变的效能。
Pediatr Radiol. 2022 Jun;52(7):1306-1313. doi: 10.1007/s00247-022-05313-x. Epub 2022 Mar 1.
4
The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper.加拿大儿科参考区间实验室倡议：CALIPER 白皮书。
Crit Rev Clin Lab Sci. 2017 Sep;54(6):358-413. doi: 10.1080/10408363.2017.1379945. Epub 2017 Oct 11.
5
NASPGHAN Clinical Practice Guideline for the Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease in Children: Recommendations from the Expert Committee on NAFLD (ECON) and the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN).NASPGHAN儿童非酒精性脂肪性肝病诊断与治疗临床实践指南：非酒精性脂肪性肝病专家委员会（ECON）及北美儿科胃肠病学、肝病学和营养学会（NASPGHAN）的建议
J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):319-334. doi: 10.1097/MPG.0000000000001482.
6
The Prevalence of Non-Alcoholic Fatty Liver Disease in Children and Adolescents: A Systematic Review and Meta-Analysis.儿童和青少年非酒精性脂肪性肝病的患病率：一项系统评价和荟萃分析。
PLoS One. 2015 Oct 29;10(10):e0140908. doi: 10.1371/journal.pone.0140908. eCollection 2015.
7
Hepatorenal index as an accurate, simple, and effective tool in screening for steatosis.肝肾功能指数作为一种准确、简单、有效的脂肪变性筛查工具。
AJR Am J Roentgenol. 2012 Nov;199(5):997-1002. doi: 10.2214/AJR.11.6677.