Linden J V, Hopfer S M, Gossling H R, Sunderman F W
Ann Clin Lab Sci. 1985 Nov-Dec;15(6):459-64.
Nickel concentrations were analyzed by electrothermal atomic absorption spectrophotometry in serum and whole blood specimens from patients 9 to 15 years after unilateral (N = 11) or bilateral (N = 2) hip arthroplasty. The hip prostheses were of the "Charnley" or "TR-28" (metal-to-plastic) types, fabricated of stainless-steel (14 to 16 percent Ni) with polyethylene acetabular cups. In 12 of the 13 patients, nickel concentrations (+/- SD) averaged 0.30 +/- 0.25 microgram per L (range 0.05 to 0.85) in serum and 0.36 +/- 0.20 microgram per L (range 0.11 to 0.67) in whole blood; these values did not differ significantly from the corresponding nickel concentrations in specimens from 30 healthy controls (0.28 +/- 0.24 microgram per L, range less than 0.05 to 1.08, in serum; 0.34 +/- 0.28 microgram per L, range less than 0.05 to 1.05, in whole blood). The remaining patient, a 78-year-old man with bilateral hip arthroplasty, had nickel concentrations of 3.1 micrograms per L in serum and 2.3 micrograms per L in whole blood; renal insufficiency apparently contributed to hypernickelemia in this patient. The arthroplasty patients were asymptomatic with respect to their joint replacements; X-rays at the last follow-up examinations did not reveal bone resorption around the implants. This study shows that patients with stainless-steel hip prostheses of the metal-to-plastic types do not develop hypernickelemia in the apparent absence of corrosion, local complications, or systemic conditions, such as renal insufficiency.
采用电热原子吸收分光光度法对单侧（N = 11）或双侧（N = 2）髋关节置换术后9至15年患者的血清和全血样本中的镍浓度进行了分析。髋关节假体为“Charnley”型或“TR - 28”型（金属对塑料），由含14%至16%镍的不锈钢制成，并配有聚乙烯髋臼杯。在13例患者中的12例中，血清镍浓度（±标准差）平均为0.30±0.25微克/升（范围0.05至0.85），全血镍浓度为0.36±0.20微克/升（范围0.11至0.67）；这些值与30名健康对照样本中的相应镍浓度无显著差异（血清中为0.28±0.24微克/升，范围小于0.05至1.08；全血中为0.34±0.28微克/升，范围小于0.05至1.05）。其余1例患者为一名78岁双侧髋关节置换男性，血清镍浓度为3.1微克/升，全血镍浓度为2.3微克/升；肾功能不全显然导致了该患者的高镍血症。这些接受关节置换术的患者在关节置换方面无症状；最后一次随访检查的X线片未显示植入物周围的骨质吸收。本研究表明，在明显没有腐蚀、局部并发症或全身性疾病（如肾功能不全）的情况下，使用金属对塑料类型不锈钢髋关节假体的患者不会发生高镍血症。
