Demir Temir Ali, Akar Tamer, Akyüz Fahrettin, Işikli Burhanettin, Kanbak Güngör
Department of Chemistry, Faculty of Arts and Sciences, Osmangazi University, Eskişehir, Turkey.
Environ Monit Assess. 2005 May;104(1-3):437-44. doi: 10.1007/s10661-005-2281-5.
The aim of this study was to determine the concentrations of nickel and cadmium in blood plasma of the people exposed to cement dust emissions and to investigate the effects of exposure period on the activities of Na+/K+ ATPase enzymes in their erythrocyte membranes. The study was carried out on people living in Eskişehir Cukurhisar rural area, located near a cement factory. Blood samples of the individuals residing in this area were taken from 80 subjects (30 for control) following a physical examination. The analysis of plasma samples showed that nickel concentrations in subject group were found to be significantly higher than those of the control group (p < 0.001). Cadmium concentrations were found to be within the reference values for both group and no difference was found between the subjects and controls (p > 0.05). Furthermore, no correlation was observed between the levels of Na+/K+ ATPase activity in erythrocyte membranes of the subject group and the ages of people living in the region (p > 0.05, r = 0.133). It was also observed that nickel concentrations increased by age (p < 0.001, r = 0.646) while no effect was observed in means of cadmium. Na+/K+ ATPase activities in the erythrocyte membranes were not affected. In conclusion although there was no difference between the Na+/K+ ATPase activity in means of age, there was an environmental pollution and may be it was due to the industrial plant.
本研究的目的是测定接触水泥粉尘排放的人群血浆中镍和镉的浓度，并研究接触时间对其红细胞膜中Na+/K+ ATP酶活性的影响。该研究针对居住在靠近水泥厂的埃斯基谢希尔库克希萨尔农村地区的人群展开。在对该地区居民进行体检后，从80名受试者（30名作为对照组）采集血样。血浆样本分析显示，受试者组中的镍浓度显著高于对照组（p < 0.001）。两组的镉浓度均在参考值范围内，受试者与对照组之间未发现差异（p > 0.05）。此外，受试者组红细胞膜中Na+/K+ ATP酶活性水平与该地区居民年龄之间未观察到相关性（p > 0.05，r = 0.133）。还观察到镍浓度随年龄增加（p < 0.001，r = 0.646），而镉的均值未观察到影响。红细胞膜中的Na+/K+ ATP酶活性未受影响。总之，尽管年龄均值在Na+/K+ ATP酶活性方面没有差异，但存在环境污染，这可能归因于工业工厂。
