Guo Min, Cao Jian-Nan, Li Xiao-Dong, Jin Ling
Laboratory of Chinese Medicine, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, 730050, China.
College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
Curr Med Sci. 2025 Jul 7. doi: 10.1007/s11596-025-00079-3.
Alcoholic liver disease (ALD), which includes a range of diseases, ranging from alcoholic steatosis, hepatitis, and fibrosis to cirrhosis and hepatocarcinoma, is a process of epigenetic remodeling involving multiple genes and metabolic pathways. ALD is involved in various transcriptional regulatory mechanisms, including lipid metabolism disorders, inflammatory responses, autophagy, fibrogenesis, oxidative stress, fatty acid metabolism, iron metabolism, and endoplasmic reticulum stress. In the occurrence of ALD and its response to the microenvironment, various transcription factors (TFs) play important roles. Targeted therapy involving these TFs may pave a novel avenue for the treatment of ALD. Here, we summarize the molecular characteristics of TFs and their involvement in the biological and pathological processes of ALD. We further discuss the current pharmaceutical treatments targeting these TFs and their mediators. This study provides detailed and accurate regulation maps of TFs for the targeted therapy of ALD.
酒精性肝病（ALD）包括一系列疾病，从酒精性脂肪变性、肝炎、纤维化到肝硬化和肝癌，是一个涉及多个基因和代谢途径的表观遗传重塑过程。ALD涉及多种转录调控机制，包括脂质代谢紊乱、炎症反应、自噬、纤维生成、氧化应激、脂肪酸代谢、铁代谢和内质网应激。在ALD的发生及其对微环境的反应中，各种转录因子（TFs）发挥着重要作用。针对这些TFs的靶向治疗可能为ALD的治疗开辟一条新途径。在此，我们总结了TFs的分子特征及其在ALD生物学和病理过程中的作用。我们进一步讨论了目前针对这些TFs及其介质的药物治疗。本研究为ALD的靶向治疗提供了详细准确的TFs调控图谱。
