Stemmer K L, Petering H G, Murthy L, Finelli V N, Menden E E
Ann Nutr Metab. 1985;29(6):332-47. doi: 10.1159/000176990.
Weanling rats were fed a copper-deficient purified diet. The effects of varying the type of protein and supplements of copper and zinc on cardiovascular pathology and some biochemical parameters were investigated. It was found that cardiomyopathy developed in the copper-deficient groups. Milk powder caused significant exacerbation of this development relative to dietary casein or egg white. Angiopathy developed only when dietary zinc was 20 ppm. Dietary copper did not change this situation. Serum cholesterol was elevated when copper was low and casein or milk powder were the protein source. The data point to an interaction between type of protein and dietary copper or zinc in the pathogenesis of cardiovascular lesions.
给断奶大鼠喂食缺铜的纯化日粮。研究了改变蛋白质类型以及铜和锌补充剂对心血管病理和一些生化参数的影响。结果发现，缺铜组出现了心肌病。相对于日粮中的酪蛋白或蛋清，奶粉会使这种病变显著加重。仅当日粮锌含量为20 ppm时才会出现血管病。日粮铜含量并未改变这种情况。当铜含量低且酪蛋白或奶粉为蛋白质来源时，血清胆固醇升高。这些数据表明，在心血管病变的发病机制中，蛋白质类型与日粮铜或锌之间存在相互作用。
