Fields M, Lewis C G, Lure M D
Georgetown University Medical Center, Division of Endocrinology, Washington, DC.
J Am Coll Nutr. 1993 Jun;12(3):303-6. doi: 10.1080/07315724.1993.10718314.
The present investigation was conducted to determine whether type of dietary protein can exacerbate the pathology induced by the combination of fructose feeding and copper (Cu) deficiency. Weanling male Sprague-Dawley rats were assigned to three different groups differing in the nature of dietary protein. The proteins used were egg-white, casein or lactalbumin. All diets contained 62.5% carbohydrate as fructose and were low in Cu (0.6-0.72 microgram Cu/g diet). Although the lowest concentration of Cu was found in the livers of rats fed egg-white, the pathology associated with Cu deficiency was more severe in rats fed lactalbumin. The highest concentration of hepatic Cu was found in rats fed casein. The data show that the type of dietary protein can exacerbate signs associated with Cu deficiency. The concentrations of hepatic Cu do not reflect accurately the pathology associated with Cu deficiency.
进行本研究是为了确定膳食蛋白质的类型是否会加剧果糖喂养和铜（Cu）缺乏共同导致的病理状况。将断乳雄性斯普拉格-道利大鼠分为三组，每组膳食蛋白质的性质不同。所使用的蛋白质分别是蛋清、酪蛋白或乳白蛋白。所有饮食中碳水化合物含量的62.5%为果糖，且铜含量较低（0.6 - 0.72微克铜/克饮食）。尽管喂食蛋清的大鼠肝脏中铜的浓度最低，但喂食乳白蛋白的大鼠中与铜缺乏相关的病理状况更为严重。喂食酪蛋白的大鼠肝脏中铜的浓度最高。数据表明，膳食蛋白质的类型会加剧与铜缺乏相关的症状。肝脏中铜的浓度并不能准确反映与铜缺乏相关的病理状况。
