Stang-Voss C, Appell H J
Anticancer Res. 1985 Sep-Oct;5(5):517-20.
Syngenic macrophages "conditioned" in the supernatant of a S-180 sarcoma cell culture were applied to mice. When inoculating S-180 cells into these mice later, they only rarely developed a tumor of smaller size compared to control animals which had not previously received conditioned macrophages. To achieve such an adopted immunity, it is important to keep the time short between trypsinization of macrophages and their injection to the host. Since human macrophages can easily be obtained, this method may present a perspective for tumor prevention in man.
将在S-180肉瘤细胞培养上清液中“预处理”的同基因巨噬细胞应用于小鼠。之后当将S-180细胞接种到这些小鼠体内时，与之前未接受预处理巨噬细胞的对照动物相比，它们很少长出较小的肿瘤。为实现这种获得性免疫，巨噬细胞胰蛋白酶消化后与注射到宿主之间的时间间隔保持短暂很重要。由于人巨噬细胞很容易获得，该方法可能为人类肿瘤预防提供一个前景。
