Kohchi Chie, Inagawa Hiroyuki, Hino Mami, Oda Mutsumi, Nakata Kazue, Yoshida Aya, Hori Hitoshi, Terada Hiroshi, Makino Kimiko, Takiguchi Kunio, Soma Gen-Ichiro
Institute for Health Science, Tokushima Bunri University, Nishihama, Yamashiro-cho, Tokushima-shi, Japan.
Anticancer Res. 2004 Sep-Oct;24(5C):3311-20.
Appropriate and rational modulation of innate immunity may enhance the therapeutic efficacy of emerging immune therapies for treating cancer. One of the crucial cells of innate immunity is the macrophage. The purpose of this article was to review those issues that suggest ways of exploiting macrophage local functions in immune therapy, and to discuss the suitability of low molecular-weight lipopolysaccharides as potent modulators of macrophage functions for immune therapy of cancer.
对先天免疫进行适当合理的调节可能会提高新兴免疫疗法治疗癌症的疗效。先天免疫的关键细胞之一是巨噬细胞。本文的目的是回顾那些提示在免疫治疗中利用巨噬细胞局部功能的方法的问题，并讨论低分子量脂多糖作为巨噬细胞功能的有效调节剂用于癌症免疫治疗的适用性。
