Ganguly Kasturi, Madan Taruna
Department of Innate Immunity, Indian Council of Medical Research (ICMR)-National Institute for Research in Reproductive and Child Health (NIRRCH), Mumbai, India.
Division of Development Research, Indian Council of Medical Research (ICMR), New Delhi, India.
Adv Exp Med Biol. 2025;1476:107-119. doi: 10.1007/978-3-031-85340-1_5.
C-type lectins (CTLs) form a broad and diverse protein superfamily with the ability to identify a wide array of ligands with their characteristic C-type lectin-like domains (CTLDs), thus governing a broad spectrum of physiological functions. CTLD-containing proteins (CTLDcps) are now classified into 17 groups based on their phylogeny and overall domain organization. While much research has centered on the role of C-type lectins in innate and adaptive antimicrobial immune responses, their significance extends further. They are increasingly acknowledged for their significant involvement in cancer biology. It has been evident that the CLR signaling can wield dual effects akin to a double-edged sword across various microbial or oncogenic scenarios. Consequently, the therapeutic potential of both agonists and antagonists targeting CLR signaling is now surfacing as innovative strategies. The growing body of evidence highlighting the indispensable role of C-type lectin receptors (CTLR) in numerous biological processes underscores the necessity for a deeper comprehension of their functional capabilities in both immune defense and disease contexts.
C型凝集素（CTLs）构成了一个广泛多样的蛋白质超家族，它们能够通过其特征性的C型凝集素样结构域（CTLDs）识别各种各样的配体，从而调控广泛的生理功能。含CTLD的蛋白质（CTLDcps）现在根据其系统发育和整体结构域组织被分为17组。虽然许多研究集中在C型凝集素在先天性和适应性抗微生物免疫反应中的作用，但其意义更为广泛。它们在癌症生物学中的重要参与越来越受到认可。很明显，在各种微生物或致癌情况下，C型凝集素受体（CLR）信号传导能像双刃剑一样产生双重作用。因此，针对CLR信号传导的激动剂和拮抗剂的治疗潜力正作为创新策略浮现出来。越来越多的证据强调了C型凝集素受体（CTLR）在众多生物学过程中不可或缺的作用，这凸显了在免疫防御和疾病背景下更深入了解其功能能力的必要性。
