[Use of bioflavonoids to prevent the harmful action of tetracycline on the liver].

It was shown in experiments on male albino rats that the plant bioflavonoids flamin, flakumin and tanaflon had hepatoprotective properties in liver function impairment caused by tetracycline intoxication. This was evident from a significant improvement of biliary secretion, synthesis and secretion of bile acids and bile secretion of bilirubin and cholesterol not only in the animals untreated with tetracycline but also in the controls. A decrease in the activity of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase in the serum was indicative of the pronounced hepatoprotective effect of the bioflavonoids. They inhibited lipid peroxidation in the hepatocyte membranes evident from a decrease in the content of malonic dialdehyde and diene conjugates in liver homogenates. The antioxidant properties were especially pronounced in tanaflon. Correlation between lipid peroxidation, activity of the transferases and alkaline phosphatase and cholopoiesis both in tetracycline intoxication and in the prophylaxis and treatment with flamin, flakumin and tanaflon was shown.