Skakun N P, Shman'ko V V, Stepanova N Iu
Antibiot Med Biotekhnol. 1985 Jun;30(6):452-6.
It was shown in experiments on male albino rats that the plant bioflavonoids flamin, flakumin and tanaflon had hepatoprotective properties in liver function impairment caused by tetracycline intoxication. This was evident from a significant improvement of biliary secretion, synthesis and secretion of bile acids and bile secretion of bilirubin and cholesterol not only in the animals untreated with tetracycline but also in the controls. A decrease in the activity of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase in the serum was indicative of the pronounced hepatoprotective effect of the bioflavonoids. They inhibited lipid peroxidation in the hepatocyte membranes evident from a decrease in the content of malonic dialdehyde and diene conjugates in liver homogenates. The antioxidant properties were especially pronounced in tanaflon. Correlation between lipid peroxidation, activity of the transferases and alkaline phosphatase and cholopoiesis both in tetracycline intoxication and in the prophylaxis and treatment with flamin, flakumin and tanaflon was shown.
在雄性白化大鼠实验中发现，植物生物类黄酮flamin、flakumin和tanaflon对四环素中毒所致肝功能损害具有肝保护特性。这不仅在未用四环素处理的动物中，而且在对照组中，从胆汁分泌、胆汁酸合成与分泌以及胆红素和胆固醇的胆汁分泌显著改善中得以体现。血清中丙氨酸转氨酶、天冬氨酸转氨酶和碱性磷酸酶活性降低表明生物类黄酮具有显著的肝保护作用。它们抑制肝细胞膜脂质过氧化，这从肝匀浆中丙二醛和二烯共轭物含量降低可以看出。抗氧化特性在tanaflon中尤为明显。研究显示了四环素中毒以及用flamin、flakumin和tanaflon预防和治疗时脂质过氧化、转氨酶和碱性磷酸酶活性与胆汁生成之间的相关性。
